Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors
Introduction Schizophrenia (SCZ) is a severe mental disorder that is among the leading causes of disability worldwide. Multiple sclerosis (MS) is a chronic inflammatory neurological disease with a major impact on the quality of life of young adults. Despite the distinct nature of these two disorder...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822020363/type/journal_article |
| _version_ | 1797617411048865792 |
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| author | H. Jemli U. Ouali S. Madouri A. Aissa R. Jomli |
| author_facet | H. Jemli U. Ouali S. Madouri A. Aissa R. Jomli |
| author_sort | H. Jemli |
| collection | DOAJ |
| description |
Introduction
Schizophrenia (SCZ) is a severe mental disorder that is among the leading causes of disability worldwide. Multiple sclerosis (MS) is a chronic inflammatory neurological disease with a major impact on the quality of life of young adults. Despite the distinct nature of these two disorders, research studies have identified similarities in underlying pathological mechanisms and risk factors.
Objectives
To illustrate, through a case report, the central role of inflammation in schizophrenia and its relationship with multiple sclerosis.
Methods
Case Report of a 31-year-old male patient with schizophrenia who has been diagnosed with multiple sclerosis.
Results
Mr M. is a 31 year old patient who was diagnosed with schizophrenia at age 17. Between the ages of 25 and 27, the patient had two severe psychotic relapses each one requiring inpatient treatment. At that time, he experienced predominantly severe positive symptoms and persistent suicidality. He was initially prescribed amisulpride up to 600mg, followed by haloperidol up to 45mg daily. Due to poor clinical response, the patient was put on clozapine 400mg/d and has been stabilized since 2017, with outpatient checkups. The patient has reported vertigo and trouble walking in August 2021. He has been referred to the Neurology Department. Clinical, biological and imaging findings were highly suggestive of Multiple sclerosis and the patient has received short courses of intravenous corticosteroids.
Conclusions
This case report highlights the possible association between Multiple Sclerosis and schizophrenia. Further research is needed to clarify the role of inflammation in the central nervous system in schizophrenia and the overlap with Multiple Sclerosis.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:54:24Z |
| format | Article |
| id | doaj.art-505f4b6f779043cc8f3d61c67ab13ebc |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:54:24Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-505f4b6f779043cc8f3d61c67ab13ebc2023-11-17T05:05:57ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S788S78810.1192/j.eurpsy.2022.2036Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factorsH. Jemli0U. Ouali1S. Madouri2A. Aissa3R. Jomli4university of tunis elmanar, Faculty Of Medicine Of Tunis, manouba, TunisiaRazi Hospital, Psychiatry A, manouba, TunisiaRazi Hospital, Psychiatry A, manouba, TunisiaRazi Hospital, Psychiatry A, manouba, TunisiaRazi Hospital, Psychiatry A, manouba, Tunisia Introduction Schizophrenia (SCZ) is a severe mental disorder that is among the leading causes of disability worldwide. Multiple sclerosis (MS) is a chronic inflammatory neurological disease with a major impact on the quality of life of young adults. Despite the distinct nature of these two disorders, research studies have identified similarities in underlying pathological mechanisms and risk factors. Objectives To illustrate, through a case report, the central role of inflammation in schizophrenia and its relationship with multiple sclerosis. Methods Case Report of a 31-year-old male patient with schizophrenia who has been diagnosed with multiple sclerosis. Results Mr M. is a 31 year old patient who was diagnosed with schizophrenia at age 17. Between the ages of 25 and 27, the patient had two severe psychotic relapses each one requiring inpatient treatment. At that time, he experienced predominantly severe positive symptoms and persistent suicidality. He was initially prescribed amisulpride up to 600mg, followed by haloperidol up to 45mg daily. Due to poor clinical response, the patient was put on clozapine 400mg/d and has been stabilized since 2017, with outpatient checkups. The patient has reported vertigo and trouble walking in August 2021. He has been referred to the Neurology Department. Clinical, biological and imaging findings were highly suggestive of Multiple sclerosis and the patient has received short courses of intravenous corticosteroids. Conclusions This case report highlights the possible association between Multiple Sclerosis and schizophrenia. Further research is needed to clarify the role of inflammation in the central nervous system in schizophrenia and the overlap with Multiple Sclerosis. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822020363/type/journal_articleinflammationmultiple sclerosisresistanceschizophrénia |
| spellingShingle | H. Jemli U. Ouali S. Madouri A. Aissa R. Jomli Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors European Psychiatry inflammation multiple sclerosis resistance schizophrénia |
| title | Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors |
| title_full | Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors |
| title_fullStr | Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors |
| title_full_unstemmed | Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors |
| title_short | Schizophrenia and Multiple Sclerosis: Common pathways, common risk-factors |
| title_sort | schizophrenia and multiple sclerosis common pathways common risk factors |
| topic | inflammation multiple sclerosis resistance schizophrénia |
| url | https://www.cambridge.org/core/product/identifier/S0924933822020363/type/journal_article |
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