The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice
Abstract Polysaccharide (PF40) has been recognized as a main bioactive substances in Pseudostellaria heterophylla (Miq.). The current study explored the potential protective effects of PF40 on immune system in mice with cyclophosphamide‐induced immunosuppression. The mice were intragastric administe...
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.2979 |
| _version_ | 1797894452121960448 |
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| author | Yongjun Kan Yingying Liu Yating Huang Li Zhao Chang Jiang Yanjin Zhu Ziqin Pang Juan Hu Wensheng Pang Wenxiong Lin |
| author_facet | Yongjun Kan Yingying Liu Yating Huang Li Zhao Chang Jiang Yanjin Zhu Ziqin Pang Juan Hu Wensheng Pang Wenxiong Lin |
| author_sort | Yongjun Kan |
| collection | DOAJ |
| description | Abstract Polysaccharide (PF40) has been recognized as a main bioactive substances in Pseudostellaria heterophylla (Miq.). The current study explored the potential protective effects of PF40 on immune system in mice with cyclophosphamide‐induced immunosuppression. The mice were intragastric administered PF40 at the dosage of 100, 200 or 400 mg/kg once daily for 30 days, On the 24th and 25th day, the additional intraperitoneal injection of PF40 (50 mg/kg) were administered. The results showed that PF40 enhanced the cell‐mediated immunity via improvements in macrophage phagocytosis, splenocyte proliferation, NK cell activity and delayed type hypersensitivity. Equally, it improves humoral immunity through promoting the formation of serum hemolysin. Moreover, PF40 maintain the immune balance of splenic lymphocytes and altered the intestinal physiological status in Cyp‐induced mice. PF40 regulates the intestinal microbiota by restoring the relative abundance of Odoribacter and Mucispirillum and reducing the relative abundance of Sporosarcina, Yaniella, and Jeotgalicoccus in Cyp‐intervened mice. The findings suggested that PF40 might be a promising natural functional foods for reducing chemotherapy‐induced immunosuppression. |
| first_indexed | 2024-04-10T07:10:27Z |
| format | Article |
| id | doaj.art-505fc7ee2e8d4e798edf7c00119ab2cd |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-10T07:10:27Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-505fc7ee2e8d4e798edf7c00119ab2cd2023-02-26T13:10:39ZengWileyFood Science & Nutrition2048-71772022-11-0110113828384110.1002/fsn3.2979The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed miceYongjun Kan0Yingying Liu1Yating Huang2Li Zhao3Chang Jiang4Yanjin Zhu5Ziqin Pang6Juan Hu7Wensheng Pang8Wenxiong Lin9Fujian Agriculture and Forestry University Fuzhou ChinaThe Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine Fuzhou ChinaFujian University of Traditional Chinese Medicine Fuzhou ChinaFujian Academy of Chinese Medical Sciences Fuzhou ChinaFujian Academy of Chinese Medical Sciences Fuzhou ChinaFujian University of Traditional Chinese Medicine Fuzhou ChinaFujian Agriculture and Forestry University Fuzhou ChinaFujian Academy of Chinese Medical Sciences Fuzhou ChinaThe Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine Fuzhou ChinaFujian Agriculture and Forestry University Fuzhou ChinaAbstract Polysaccharide (PF40) has been recognized as a main bioactive substances in Pseudostellaria heterophylla (Miq.). The current study explored the potential protective effects of PF40 on immune system in mice with cyclophosphamide‐induced immunosuppression. The mice were intragastric administered PF40 at the dosage of 100, 200 or 400 mg/kg once daily for 30 days, On the 24th and 25th day, the additional intraperitoneal injection of PF40 (50 mg/kg) were administered. The results showed that PF40 enhanced the cell‐mediated immunity via improvements in macrophage phagocytosis, splenocyte proliferation, NK cell activity and delayed type hypersensitivity. Equally, it improves humoral immunity through promoting the formation of serum hemolysin. Moreover, PF40 maintain the immune balance of splenic lymphocytes and altered the intestinal physiological status in Cyp‐induced mice. PF40 regulates the intestinal microbiota by restoring the relative abundance of Odoribacter and Mucispirillum and reducing the relative abundance of Sporosarcina, Yaniella, and Jeotgalicoccus in Cyp‐intervened mice. The findings suggested that PF40 might be a promising natural functional foods for reducing chemotherapy‐induced immunosuppression.https://doi.org/10.1002/fsn3.2979gut floraimmunomodulatory activityimmunosuppressedpolysaccharidesPseudostellaria heterophylla |
| spellingShingle | Yongjun Kan Yingying Liu Yating Huang Li Zhao Chang Jiang Yanjin Zhu Ziqin Pang Juan Hu Wensheng Pang Wenxiong Lin The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice Food Science & Nutrition gut flora immunomodulatory activity immunosuppressed polysaccharides Pseudostellaria heterophylla |
| title | The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| title_full | The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| title_fullStr | The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| title_full_unstemmed | The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| title_short | The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| title_sort | regulatory effects of pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice |
| topic | gut flora immunomodulatory activity immunosuppressed polysaccharides Pseudostellaria heterophylla |
| url | https://doi.org/10.1002/fsn3.2979 |
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