Autoimmune myasthenia gravis and COVID-19. A case report-based review
A potential relationship between COVID-19 infection and new onset myasthenia gravis (MG) has been suggested by the coexistence of these two diseases in a number of reports. This study aimed to assess their relationship by reviewing case studies of COVID-19 followed by new onset MG published between...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-08-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231191025 |
| _version_ | 1797744830087954432 |
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| author | Cristina Georgiana Croitoru Dan Iulian Cuciureanu Diana Nicoleta Hodorog Cristina Grosu Petru Cianga |
| author_facet | Cristina Georgiana Croitoru Dan Iulian Cuciureanu Diana Nicoleta Hodorog Cristina Grosu Petru Cianga |
| author_sort | Cristina Georgiana Croitoru |
| collection | DOAJ |
| description | A potential relationship between COVID-19 infection and new onset myasthenia gravis (MG) has been suggested by the coexistence of these two diseases in a number of reports. This study aimed to assess their relationship by reviewing case studies of COVID-19 followed by new onset MG published between 01 December 2019 and 30 June 2023 identified by a search of PubMed/Medline database. In addition, we reviewed evidence in favour and against a potential cause and effect association, and described possible mechanisms that would underpin such a relationship. We identified 14 publications that reported 18 cases. Analysis showed the following features: age 19–83 years; 10 men/8 women; median time interval between COVID-19 and MG (17, 5–56 days); autoimmune comorbidities (4); generalised MG (14); ocular MG (4); thymoma (3); antiacetylcholine receptor antibody (16); antimuscle-specific kinase antibodies (2). All patients improved following treatment. Proof of direct causality between the two conditions can only be established in time by confirming epidemiological increase in the incidence of MG or elucidating pathogenic mechanisms to substantiate a possible cause-effect association, or both. |
| first_indexed | 2024-03-12T15:14:54Z |
| format | Article |
| id | doaj.art-506062326b6044ad8de3150f87348430 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-12T15:14:54Z |
| publishDate | 2023-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-506062326b6044ad8de3150f873484302023-08-11T14:03:24ZengSAGE PublishingJournal of International Medical Research1473-23002023-08-015110.1177/03000605231191025Autoimmune myasthenia gravis and COVID-19. A case report-based reviewCristina Georgiana CroitoruDan Iulian CuciureanuDiana Nicoleta HodorogCristina GrosuPetru CiangaA potential relationship between COVID-19 infection and new onset myasthenia gravis (MG) has been suggested by the coexistence of these two diseases in a number of reports. This study aimed to assess their relationship by reviewing case studies of COVID-19 followed by new onset MG published between 01 December 2019 and 30 June 2023 identified by a search of PubMed/Medline database. In addition, we reviewed evidence in favour and against a potential cause and effect association, and described possible mechanisms that would underpin such a relationship. We identified 14 publications that reported 18 cases. Analysis showed the following features: age 19–83 years; 10 men/8 women; median time interval between COVID-19 and MG (17, 5–56 days); autoimmune comorbidities (4); generalised MG (14); ocular MG (4); thymoma (3); antiacetylcholine receptor antibody (16); antimuscle-specific kinase antibodies (2). All patients improved following treatment. Proof of direct causality between the two conditions can only be established in time by confirming epidemiological increase in the incidence of MG or elucidating pathogenic mechanisms to substantiate a possible cause-effect association, or both.https://doi.org/10.1177/03000605231191025 |
| spellingShingle | Cristina Georgiana Croitoru Dan Iulian Cuciureanu Diana Nicoleta Hodorog Cristina Grosu Petru Cianga Autoimmune myasthenia gravis and COVID-19. A case report-based review Journal of International Medical Research |
| title | Autoimmune myasthenia gravis and COVID-19. A case report-based review |
| title_full | Autoimmune myasthenia gravis and COVID-19. A case report-based review |
| title_fullStr | Autoimmune myasthenia gravis and COVID-19. A case report-based review |
| title_full_unstemmed | Autoimmune myasthenia gravis and COVID-19. A case report-based review |
| title_short | Autoimmune myasthenia gravis and COVID-19. A case report-based review |
| title_sort | autoimmune myasthenia gravis and covid 19 a case report based review |
| url | https://doi.org/10.1177/03000605231191025 |
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