Investigating the level of Hba1c and insulin level in β-thalassemia patients
Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including...
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| Format: | Article |
| Language: | English |
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Universitas Muhammadiyah Purwokerto
2023-12-01
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| Series: | Medisains |
| Subjects: | |
| Online Access: | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/18362 |
| _version_ | 1797371689395290112 |
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| author | Husnan Mujiburrahman Qodri Santosa Joko Setyono Nendyah Roestijawati Lantip Rujito |
| author_facet | Husnan Mujiburrahman Qodri Santosa Joko Setyono Nendyah Roestijawati Lantip Rujito |
| author_sort | Husnan Mujiburrahman |
| collection | DOAJ |
| description | Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.
Objective: This study aimed to describe HbA1c and insulin levels of β-thalassemia patients. The study also tested whether there was a significant difference in insulin and HbA1c levels among patients with different β-thalassemia categories.
Method: This research was an analytic observational study. The samples were taken by total sampling and involved 30 patients, and the examination was carried out using the patient's blood plasma.
Result: The study found that samples had low HbA1c levels. There was no significant mean difference (p>0.05) between insulin and HbA1c in the mild, moderate, and severe clinical degree groups. There was no significant difference in average (p>0.05) insulin and HbA1c in the thalassemia sufferers with allele β+ and β0 types.
Conclusion: There was a decrease in insulin and HbA1c in patients with β-thalassemia, which may be caused by damage pancreatic organ damage. |
| first_indexed | 2024-03-08T18:24:27Z |
| format | Article |
| id | doaj.art-5060e308cb914f63ae00aa0531088b2b |
| institution | Directory Open Access Journal |
| issn | 1693-7309 2621-2366 |
| language | English |
| last_indexed | 2024-03-08T18:24:27Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Muhammadiyah Purwokerto |
| record_format | Article |
| series | Medisains |
| spelling | doaj.art-5060e308cb914f63ae00aa0531088b2b2023-12-30T15:27:38ZengUniversitas Muhammadiyah PurwokertoMedisains1693-73092621-23662023-12-01213859010.30595/medisains.v21i3.183625755Investigating the level of Hba1c and insulin level in β-thalassemia patientsHusnan Mujiburrahman0Qodri Santosa1Joko Setyono2Nendyah Roestijawati3Lantip Rujito4faculty of medicine Universitas Jenderal SoedirmanFaculty of Medicine Universitas Jenderal SoedirmanFaculty of Medicine Universitas Jenderal SoedirmanFaculty of Medicine Universitas Jenderal SoedirmanFaculty of Medicine Universitas Jenderal SoedirmanBackground: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs. Objective: This study aimed to describe HbA1c and insulin levels of β-thalassemia patients. The study also tested whether there was a significant difference in insulin and HbA1c levels among patients with different β-thalassemia categories. Method: This research was an analytic observational study. The samples were taken by total sampling and involved 30 patients, and the examination was carried out using the patient's blood plasma. Result: The study found that samples had low HbA1c levels. There was no significant mean difference (p>0.05) between insulin and HbA1c in the mild, moderate, and severe clinical degree groups. There was no significant difference in average (p>0.05) insulin and HbA1c in the thalassemia sufferers with allele β+ and β0 types. Conclusion: There was a decrease in insulin and HbA1c in patients with β-thalassemia, which may be caused by damage pancreatic organ damage.https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/18362beta-thalassemiaglycated hemoglobininsulins |
| spellingShingle | Husnan Mujiburrahman Qodri Santosa Joko Setyono Nendyah Roestijawati Lantip Rujito Investigating the level of Hba1c and insulin level in β-thalassemia patients Medisains beta-thalassemia glycated hemoglobin insulins |
| title | Investigating the level of Hba1c and insulin level in β-thalassemia patients |
| title_full | Investigating the level of Hba1c and insulin level in β-thalassemia patients |
| title_fullStr | Investigating the level of Hba1c and insulin level in β-thalassemia patients |
| title_full_unstemmed | Investigating the level of Hba1c and insulin level in β-thalassemia patients |
| title_short | Investigating the level of Hba1c and insulin level in β-thalassemia patients |
| title_sort | investigating the level of hba1c and insulin level in β thalassemia patients |
| topic | beta-thalassemia glycated hemoglobin insulins |
| url | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/18362 |
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