Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary
Background: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. Objective: To study the epidemiologic data and clinical prese...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328722001341 |
| _version_ | 1811166393880543232 |
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| author | Danica Xie, MD Asli Bilgic, MD Nada Abu Alrub, MBBS Özlem Dicle, MD Dédée F. Murrell, MA, BMBCh, FRCP, MD, DSc |
| author_facet | Danica Xie, MD Asli Bilgic, MD Nada Abu Alrub, MBBS Özlem Dicle, MD Dédée F. Murrell, MA, BMBCh, FRCP, MD, DSc |
| author_sort | Danica Xie, MD |
| collection | DOAJ |
| description | Background: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. Objective: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. Methods: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. Results: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). Limitations: The small sample size and lack of severe cases. Conclusion: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity. |
| first_indexed | 2024-04-10T15:51:37Z |
| format | Article |
| id | doaj.art-50613621086d46449f1bf55aeda9a9af |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-04-10T15:51:37Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-50613621086d46449f1bf55aeda9a9af2023-02-11T04:16:22ZengElsevierJAAD International2666-32872023-03-0110613Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule SummaryDanica Xie, MD0Asli Bilgic, MD1Nada Abu Alrub, MBBS2Özlem Dicle, MD3Dédée F. Murrell, MA, BMBCh, FRCP, MD, DSc4Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, AustraliaDepartment of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; Department of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya, Turkey; Correspondence to: Asli Bilgic, MD, Department of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya 07059, Turkey.Department of Dermatology, St George Hospital, Sydney, New South Wales, AustraliaDepartment of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya, TurkeyDepartment of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, AustraliaBackground: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. Objective: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. Methods: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. Results: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). Limitations: The small sample size and lack of severe cases. Conclusion: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity.http://www.sciencedirect.com/science/article/pii/S2666328722001341alopeciaautoimmune blistering diseasesdermoscopypemphigoidpemphigustrichoscopy |
| spellingShingle | Danica Xie, MD Asli Bilgic, MD Nada Abu Alrub, MBBS Özlem Dicle, MD Dédée F. Murrell, MA, BMBCh, FRCP, MD, DSc Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary JAAD International alopecia autoimmune blistering diseases dermoscopy pemphigoid pemphigus trichoscopy |
| title | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary |
| title_full | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary |
| title_fullStr | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary |
| title_full_unstemmed | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary |
| title_short | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional studyCapsule Summary |
| title_sort | clinical manifestations of alopecia in autoimmune blistering diseases a cross sectional studycapsule summary |
| topic | alopecia autoimmune blistering diseases dermoscopy pemphigoid pemphigus trichoscopy |
| url | http://www.sciencedirect.com/science/article/pii/S2666328722001341 |
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