SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE
Crosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were char...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2011-07-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/21413 |
| _version_ | 1831630871357030400 |
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| author | Erizal Erizal Thamrin Wikanta |
| author_facet | Erizal Erizal Thamrin Wikanta |
| author_sort | Erizal Erizal |
| collection | DOAJ |
| description | Crosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were characterized by Fourier transform infra red spectroscopy and their physico-chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and antimicrobial activities. It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 20 kGy, PEO-chitosan hydrogels with high gel fraction (85%), swelling ratio (10 g/g) and elongation at break (145%) were obtained. The examination of the microbe penetration shows that the prepared hydrogels can be considered as a good barrier against microbes. Thus, PEO-chitosan hydrogel showed satisfactory properties for use as a wound dressing. |
| first_indexed | 2024-12-19T04:51:36Z |
| format | Article |
| id | doaj.art-50622727fc4e49ee863addb64f175100 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-19T04:51:36Z |
| publishDate | 2011-07-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-50622727fc4e49ee863addb64f1751002022-12-21T20:35:21ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782011-07-01111162010.22146/ijc.2141314511SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUEErizal Erizal0Thamrin Wikanta1Centre for the Applications Isotope and Radiation Technology, National Nuclear Agency, Jl. Lebak Bulus Raya no.49, Jakarta 12440Centre Research for Product Processing and Biotechnology Marine & Fisheries, Jl. K.S. Tubun VI, Jakarta 10260Crosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were characterized by Fourier transform infra red spectroscopy and their physico-chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and antimicrobial activities. It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 20 kGy, PEO-chitosan hydrogels with high gel fraction (85%), swelling ratio (10 g/g) and elongation at break (145%) were obtained. The examination of the microbe penetration shows that the prepared hydrogels can be considered as a good barrier against microbes. Thus, PEO-chitosan hydrogel showed satisfactory properties for use as a wound dressing.https://jurnal.ugm.ac.id/ijc/article/view/21413Gamma radiationpolyethylene oxidechitosanhydrogelwound dressing |
| spellingShingle | Erizal Erizal Thamrin Wikanta SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE Indonesian Journal of Chemistry Gamma radiation polyethylene oxide chitosan hydrogel wound dressing |
| title | SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE |
| title_full | SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE |
| title_fullStr | SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE |
| title_full_unstemmed | SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE |
| title_short | SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE |
| title_sort | synthesis of polyethylene oxide peo chitosan hydrogel prepared by gamma radiation technique |
| topic | Gamma radiation polyethylene oxide chitosan hydrogel wound dressing |
| url | https://jurnal.ugm.ac.id/ijc/article/view/21413 |
| work_keys_str_mv | AT erizalerizal synthesisofpolyethyleneoxidepeochitosanhydrogelpreparedbygammaradiationtechnique AT thamrinwikanta synthesisofpolyethyleneoxidepeochitosanhydrogelpreparedbygammaradiationtechnique |