Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research
Reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen Chlamydia trachomatis in some individuals. Recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen Chlamydia pneumonia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-2607/4/3/30 |
| _version_ | 1811209338462666752 |
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| author | Henning Zeidler Alan P Hudson |
| author_facet | Henning Zeidler Alan P Hudson |
| author_sort | Henning Zeidler |
| collection | DOAJ |
| description | Reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen Chlamydia trachomatis in some individuals. Recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen Chlamydia pneumoniae, can elicit a similar arthritis. Studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. However, reports focusing on coinfections with these and/or other organisms, and the effects of such coinfections on the host immune and other systems, have been rare. In this article, we review the extant data regarding infections by multiple pathogens in the joint as they relate to engendering arthritis, and we suggest a number of research areas that must be given a high priority if we are to understand, and therefore to treat in an effective manner, such arthritides. |
| first_indexed | 2024-04-12T04:37:50Z |
| format | Article |
| id | doaj.art-506254d343624b7d91e666dfe25c5332 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-12T04:37:50Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-506254d343624b7d91e666dfe25c53322022-12-22T03:47:45ZengMDPI AGMicroorganisms2076-26072016-08-01433010.3390/microorganisms4030030microorganisms4030030Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future ResearchHenning Zeidler0Alan P Hudson1Division of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover 30625, GermanyDepartment of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USAReactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen Chlamydia trachomatis in some individuals. Recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen Chlamydia pneumoniae, can elicit a similar arthritis. Studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. However, reports focusing on coinfections with these and/or other organisms, and the effects of such coinfections on the host immune and other systems, have been rare. In this article, we review the extant data regarding infections by multiple pathogens in the joint as they relate to engendering arthritis, and we suggest a number of research areas that must be given a high priority if we are to understand, and therefore to treat in an effective manner, such arthritides.http://www.mdpi.com/2076-2607/4/3/30Chlamydia trachomatisChlamydia pneumoniaeinfectioninflammatory arthritisundifferentiated spondyloarthritidescoinfection |
| spellingShingle | Henning Zeidler Alan P Hudson Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research Microorganisms Chlamydia trachomatis Chlamydia pneumoniae infection inflammatory arthritis undifferentiated spondyloarthritides coinfection |
| title | Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research |
| title_full | Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research |
| title_fullStr | Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research |
| title_full_unstemmed | Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research |
| title_short | Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research |
| title_sort | coinfection of chlamydiae and other bacteria in reactive arthritis and spondyloarthritis need for future research |
| topic | Chlamydia trachomatis Chlamydia pneumoniae infection inflammatory arthritis undifferentiated spondyloarthritides coinfection |
| url | http://www.mdpi.com/2076-2607/4/3/30 |
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