The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature
Objective To determine the relationship between use of nebulized heparin and clinical outcomes in mechanically ventilated patients. Methods The Medline, Embase, Web of Science, Cochrane Library, and PubMed databases were searched for relevant randomized controlled trials (RCTs), published between da...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231201340 |
| _version_ | 1797662252387532800 |
|---|---|
| author | Yi Zhang Qiankun Li Changan Sun Yue Gu Zhijiang Qi Jun Li |
| author_facet | Yi Zhang Qiankun Li Changan Sun Yue Gu Zhijiang Qi Jun Li |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | Objective To determine the relationship between use of nebulized heparin and clinical outcomes in mechanically ventilated patients. Methods The Medline, Embase, Web of Science, Cochrane Library, and PubMed databases were searched for relevant randomized controlled trials (RCTs), published between database inception and May 2022. Primary outcomes were intensive care unit (ICU) length of stay and in-hospital mortality; secondary outcomes included duration of mechanical ventilation, ventilator-free days (VFDs) in 28 days, and length of hospitalization. The study protocol was registered on PROSPERO (registration No: CRD42022345533). Results A total of eight RCTs (651 patients) were included. Nebulized heparin was associated with reduced ICU length of stay (six studies; mean difference [MD] –1.10, 95% confidence interval [CI] –1.87, –0.33, I 2 = 76%), reduced duration of mechanical ventilation (two studies; MD –2.63, 95% CI –3.68, –1.58, I 2 = 92%) and increased VFDs in 28 days (two studies; MD 4.22, 95% CI 1.10, 7.35, I 2 = 18%), without increased incidence of adverse events, such as bleeding; but was not associated with a reduction in length of hospitalization (three studies; MD –1.00, 95% CI –2.90, –0.90, I 2 = 0%) or in-hospital mortality (five studies; odds ratio 1.10, 95% CI 0.69, 1.77, I 2 = 0%). Conclusion Nebulized heparin reduces ICU length of stay and duration of mechanical ventilation in mechanically ventilated patients, but has no effect on length of hospitalization or mortality. |
| first_indexed | 2024-03-11T18:57:30Z |
| format | Article |
| id | doaj.art-5064642c9b27406a9fa0c92df9ee1fa9 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-11T18:57:30Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-5064642c9b27406a9fa0c92df9ee1fa92023-10-10T18:03:24ZengSAGE PublishingJournal of International Medical Research1473-23002023-10-015110.1177/03000605231201340The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literatureYi ZhangQiankun LiChangan SunYue GuZhijiang QiJun LiObjective To determine the relationship between use of nebulized heparin and clinical outcomes in mechanically ventilated patients. Methods The Medline, Embase, Web of Science, Cochrane Library, and PubMed databases were searched for relevant randomized controlled trials (RCTs), published between database inception and May 2022. Primary outcomes were intensive care unit (ICU) length of stay and in-hospital mortality; secondary outcomes included duration of mechanical ventilation, ventilator-free days (VFDs) in 28 days, and length of hospitalization. The study protocol was registered on PROSPERO (registration No: CRD42022345533). Results A total of eight RCTs (651 patients) were included. Nebulized heparin was associated with reduced ICU length of stay (six studies; mean difference [MD] –1.10, 95% confidence interval [CI] –1.87, –0.33, I 2 = 76%), reduced duration of mechanical ventilation (two studies; MD –2.63, 95% CI –3.68, –1.58, I 2 = 92%) and increased VFDs in 28 days (two studies; MD 4.22, 95% CI 1.10, 7.35, I 2 = 18%), without increased incidence of adverse events, such as bleeding; but was not associated with a reduction in length of hospitalization (three studies; MD –1.00, 95% CI –2.90, –0.90, I 2 = 0%) or in-hospital mortality (five studies; odds ratio 1.10, 95% CI 0.69, 1.77, I 2 = 0%). Conclusion Nebulized heparin reduces ICU length of stay and duration of mechanical ventilation in mechanically ventilated patients, but has no effect on length of hospitalization or mortality.https://doi.org/10.1177/03000605231201340 |
| spellingShingle | Yi Zhang Qiankun Li Changan Sun Yue Gu Zhijiang Qi Jun Li The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature Journal of International Medical Research |
| title | The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature |
| title_full | The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature |
| title_fullStr | The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature |
| title_full_unstemmed | The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature |
| title_short | The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature |
| title_sort | effect of nebulized heparin on clinical outcomes in mechanically ventilated patients a meta analysis and review of the literature |
| url | https://doi.org/10.1177/03000605231201340 |
| work_keys_str_mv | AT yizhang theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT qiankunli theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT changansun theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT yuegu theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT zhijiangqi theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT junli theeffectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT yizhang effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT qiankunli effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT changansun effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT yuegu effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT zhijiangqi effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature AT junli effectofnebulizedheparinonclinicaloutcomesinmechanicallyventilatedpatientsametaanalysisandreviewoftheliterature |