Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy
In the past decade, patients with nasopharyngeal cancer (NPC) have been deemed candidates for proton radiotherapy, due to the large and comprehensive target volumes and the necessity for the retention of the surrounding healthy tissues. In this study, we aimed to compare the incidence and severity o...
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/225 |
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| author | Pei-Wen Wu Chien-Chia Huang Yun-Shien Lee Yung-Chih Chou Kang-Hsing Fan Chien-Yu Lin Bing-Shen Huang Shih-Wei Yang Chi-Che Huang Po-Hung Chang Ta-Jen Lee Joseph Tung-Chieh Chang |
| author_facet | Pei-Wen Wu Chien-Chia Huang Yun-Shien Lee Yung-Chih Chou Kang-Hsing Fan Chien-Yu Lin Bing-Shen Huang Shih-Wei Yang Chi-Che Huang Po-Hung Chang Ta-Jen Lee Joseph Tung-Chieh Chang |
| author_sort | Pei-Wen Wu |
| collection | DOAJ |
| description | In the past decade, patients with nasopharyngeal cancer (NPC) have been deemed candidates for proton radiotherapy, due to the large and comprehensive target volumes and the necessity for the retention of the surrounding healthy tissues. In this study, we aimed to compare the incidence and severity of post-irradiation sinusitis by detecting sinus mucosa diseases (SMDs) via the magnetic resonance imaging (MRI) of patients with NPC after intensity-modulated proton therapy (IMPT) and volume-modulated arc therapy (VMAT). A total of 53 patients in the IMPT group and 54 patients in the VMAT group were enrolled in this study. There were significantly lower endoscopic scores and Lund–Mackay staging scores determined from MRI scans in the IMPT group during different follow-up periods. For the most vulnerable sinuses, the incidence and severity of SMD were the highest during the third post-radiotherapy month in both groups. These decreased steadily, and there was no significant increase in the incidence and severity of SMD during the second post-radiotherapy year in the IMPT group. Our data show that NPC patients with IMPT have a significantly lower incidence and decreased severity of SMD than those with VMAT. A better and faster recovery of sinonasal function after radiotherapy in the IMPT group was also observed. |
| first_indexed | 2024-03-10T03:46:17Z |
| format | Article |
| id | doaj.art-5064e23f992d4e488ecb1aa82826d470 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:46:17Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5064e23f992d4e488ecb1aa82826d4702023-11-23T11:18:05ZengMDPI AGCancers2072-66942022-01-0114122510.3390/cancers14010225Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton TherapyPei-Wen Wu0Chien-Chia Huang1Yun-Shien Lee2Yung-Chih Chou3Kang-Hsing Fan4Chien-Yu Lin5Bing-Shen Huang6Shih-Wei Yang7Chi-Che Huang8Po-Hung Chang9Ta-Jen Lee10Joseph Tung-Chieh Chang11Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanGenomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDepartment of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Keelung 204, TaiwanDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333, TaiwanIn the past decade, patients with nasopharyngeal cancer (NPC) have been deemed candidates for proton radiotherapy, due to the large and comprehensive target volumes and the necessity for the retention of the surrounding healthy tissues. In this study, we aimed to compare the incidence and severity of post-irradiation sinusitis by detecting sinus mucosa diseases (SMDs) via the magnetic resonance imaging (MRI) of patients with NPC after intensity-modulated proton therapy (IMPT) and volume-modulated arc therapy (VMAT). A total of 53 patients in the IMPT group and 54 patients in the VMAT group were enrolled in this study. There were significantly lower endoscopic scores and Lund–Mackay staging scores determined from MRI scans in the IMPT group during different follow-up periods. For the most vulnerable sinuses, the incidence and severity of SMD were the highest during the third post-radiotherapy month in both groups. These decreased steadily, and there was no significant increase in the incidence and severity of SMD during the second post-radiotherapy year in the IMPT group. Our data show that NPC patients with IMPT have a significantly lower incidence and decreased severity of SMD than those with VMAT. A better and faster recovery of sinonasal function after radiotherapy in the IMPT group was also observed.https://www.mdpi.com/2072-6694/14/1/225nasopharyngeal carcinomapost-irradiation sinusitissinus mucosa diseaseproton therapy |
| spellingShingle | Pei-Wen Wu Chien-Chia Huang Yun-Shien Lee Yung-Chih Chou Kang-Hsing Fan Chien-Yu Lin Bing-Shen Huang Shih-Wei Yang Chi-Che Huang Po-Hung Chang Ta-Jen Lee Joseph Tung-Chieh Chang Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy Cancers nasopharyngeal carcinoma post-irradiation sinusitis sinus mucosa disease proton therapy |
| title | Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy |
| title_full | Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy |
| title_fullStr | Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy |
| title_full_unstemmed | Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy |
| title_short | Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy |
| title_sort | post irradiation sinus mucosa disease in nasopharyngeal carcinoma patients treated with intensity modulated proton therapy |
| topic | nasopharyngeal carcinoma post-irradiation sinusitis sinus mucosa disease proton therapy |
| url | https://www.mdpi.com/2072-6694/14/1/225 |
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