Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity
Introduction Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity. Material and methods A cross-sectional study evaluated serum...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-07-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/Evaluation-of-the-adipokine-profile-adiponectin-resistin-adipsin-vaspin-and-leptin,151096,0,2.html |
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| author | Yany Magali Chamorro-Melo Omar-Javier Calixto Juan Manuel Bello-Gualtero Wilson Bautista-Molano Adriana Beltran-Ostos Consuelo Romero-Sánchez |
| author_facet | Yany Magali Chamorro-Melo Omar-Javier Calixto Juan Manuel Bello-Gualtero Wilson Bautista-Molano Adriana Beltran-Ostos Consuelo Romero-Sánchez |
| author_sort | Yany Magali Chamorro-Melo |
| collection | DOAJ |
| description | Introduction
Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity.
Material and methods
A cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis.
Results
Fifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (p = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (p = 0.033, p = 0.012, and p = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%.
Conclusions
Adipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines. |
| first_indexed | 2024-03-09T10:43:25Z |
| format | Article |
| id | doaj.art-5065baa07bf54e56bf63f3bb497ee8c5 |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-03-09T10:43:25Z |
| publishDate | 2022-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-5065baa07bf54e56bf63f3bb497ee8c52023-12-01T12:17:48ZengTermedia Publishing HouseRheumatology0034-62332084-98342022-07-0160319219910.5114/reum.2022.117839151096Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activityYany Magali Chamorro-Melo0Omar-Javier Calixto1Juan Manuel Bello-Gualtero2Wilson Bautista-Molano3Adriana Beltran-Ostos4Consuelo Romero-Sánchez5Hospital Militar Central, Rheumatology and Immunology Department, Nueva Granada Military University, Bogotá, ColombiaHospital Militar Central, Rheumatology and Immunology Department, Nueva Granada Military University, Bogotá, ColombiaHospital Militar Central, Rheumatology and Immunology Department, Nueva Granada Military University, Bogotá, ColombiaEl Bosque University,, Cellular and Molecular Immunology Group/InmuBo, Bogotá, ColombiaHospital Militar Central, Rheumatology and Immunology Department, Nueva Granada Military University, Bogotá, ColombiaEl Bosque University,, Cellular and Molecular Immunology Group/InmuBo, Bogotá, ColombiaIntroduction Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity. Material and methods A cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis. Results Fifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (p = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (p = 0.033, p = 0.012, and p = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%. Conclusions Adipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines.https://reu.termedia.pl/Evaluation-of-the-adipokine-profile-adiponectin-resistin-adipsin-vaspin-and-leptin,151096,0,2.htmlrheumatoid arthritisadipokinesdisease activity index |
| spellingShingle | Yany Magali Chamorro-Melo Omar-Javier Calixto Juan Manuel Bello-Gualtero Wilson Bautista-Molano Adriana Beltran-Ostos Consuelo Romero-Sánchez Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity Rheumatology rheumatoid arthritis adipokines disease activity index |
| title | Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity |
| title_full | Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity |
| title_fullStr | Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity |
| title_full_unstemmed | Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity |
| title_short | Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity |
| title_sort | evaluation of the adipokine profile adiponectin resistin adipsin vaspin and leptin in patients with early rheumatoid arthritis and its correlation with disease activity |
| topic | rheumatoid arthritis adipokines disease activity index |
| url | https://reu.termedia.pl/Evaluation-of-the-adipokine-profile-adiponectin-resistin-adipsin-vaspin-and-leptin,151096,0,2.html |
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