Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period?
Introduction: Benign prostatic hyperplasia (BPH) is a common disease affecting men 50 years and older. Treatment options consist of observation, pharmacological treatment, minimally invasive surgery and traditional surgery. Alpha-blockers and 5-alpha-reductase inhibitors are the primary medications...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-09-01
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| Series: | African Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110570418300547 |
| _version_ | 1818309823990595584 |
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| author | A.I. Ali A.M. Fawzy E. Ramadan M.M. El-Hawy T.K. Fathelbab A. Hussein M. Abd Elmalek Hassan L. Alshara E.R. Tawfiek |
| author_facet | A.I. Ali A.M. Fawzy E. Ramadan M.M. El-Hawy T.K. Fathelbab A. Hussein M. Abd Elmalek Hassan L. Alshara E.R. Tawfiek |
| author_sort | A.I. Ali |
| collection | DOAJ |
| description | Introduction: Benign prostatic hyperplasia (BPH) is a common disease affecting men 50 years and older. Treatment options consist of observation, pharmacological treatment, minimally invasive surgery and traditional surgery. Alpha-blockers and 5-alpha-reductase inhibitors are the primary medications used to treat BPH. Transurethral resection of the prostate (TURP) is the gold standard of surgical management of BPH. Objective: To evaluate the effect of six weeks finasteride therapy before TURP on overall surgical outcomes and early postoperative quality of life (QoL). Patients and methods: Between June 2014 and August 2016, patients with BPH at our department were randomly assigned to one of two groups: group (A) receiving 5 mg of finasteride daily for six weeks and group (B) did not receiving finasteride before TURP. All patients were assessed using a modified validated Arabic version of the International Prostate Symptom Score (IPSS). Intra operative serum hemoglobin concentration and hemoglobin concentration in irrigating fluid were recorded. One month post-surgery, IPSS, storage, voiding subscores and QoL scores were measured. Results: Out of a total of 115 patients, 98 patients completed the study. Before surgery, there was no significant difference between the two groups in prostate size (Prostate size was 54.52 ± 7.3 g in group A and 50.19 ± 6.8 g in group B, p value = 0.72), IPSS (19.86 ± 4.68 in group A vs. 21.14 ± 4.33 in group B, p value = 0.17), maximum urinary flow rate and post-void residual urine test results. No significant difference between Qol score in both groups before surgery (p value = 0.96). Group A patients had significantly less intraoperative blood loss than group B patients (308.29 ± 48.1 ml vs. 431.11 ± 96.4 ml, p = 0.001). One month postoperatively, group A patients showed greater improvement in QoL than group B patients (p = 0.03). Conclusions: Finasteride therapy for 6 weeks before TURP reduced intraoperative blood loss and statistically improved quality of life in the early postoperative period. However, larger number of patients and longer duration of follow up is recommended to confirm its clinical significance. Keywords: Finasteride, TURP, Quality of life |
| first_indexed | 2024-12-13T07:36:18Z |
| format | Article |
| id | doaj.art-5068ea6861c6425ca9a3c500a704e39d |
| institution | Directory Open Access Journal |
| issn | 1110-5704 |
| language | English |
| last_indexed | 2024-12-13T07:36:18Z |
| publishDate | 2018-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-5068ea6861c6425ca9a3c500a704e39d2022-12-21T23:55:05ZengSpringerOpenAfrican Journal of Urology1110-57042018-09-01243221225Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period?A.I. Ali0A.M. Fawzy1E. Ramadan2M.M. El-Hawy3T.K. Fathelbab4A. Hussein5M. Abd Elmalek Hassan6L. Alshara7E.R. Tawfiek8School of Medicine, Minia University, Minia University Hospital, Urology Department, Minia, 61111, Egypt; Corresponding author.School of Medicine, Minia University, Minia University Hospital, Urology Department, Minia, 61111, EgyptSchool of Medicine, Minia University, Minia University Hospital, Urology Department, Minia, 61111, EgyptSchool of Medicine, Minia University, EgyptSchool of Medicine, Minia University, Minia University Hospital, Urology Department, Minia, 61111, EgyptSchool of Medicine, Minia University, EgyptSchool of Medicine, Minia University, EgyptJackson Memorial Hospital, 117 NW 42nd Ave, # 709, Miami, Fl, 33126, USASchool of Medicine, Minia University, EgyptIntroduction: Benign prostatic hyperplasia (BPH) is a common disease affecting men 50 years and older. Treatment options consist of observation, pharmacological treatment, minimally invasive surgery and traditional surgery. Alpha-blockers and 5-alpha-reductase inhibitors are the primary medications used to treat BPH. Transurethral resection of the prostate (TURP) is the gold standard of surgical management of BPH. Objective: To evaluate the effect of six weeks finasteride therapy before TURP on overall surgical outcomes and early postoperative quality of life (QoL). Patients and methods: Between June 2014 and August 2016, patients with BPH at our department were randomly assigned to one of two groups: group (A) receiving 5 mg of finasteride daily for six weeks and group (B) did not receiving finasteride before TURP. All patients were assessed using a modified validated Arabic version of the International Prostate Symptom Score (IPSS). Intra operative serum hemoglobin concentration and hemoglobin concentration in irrigating fluid were recorded. One month post-surgery, IPSS, storage, voiding subscores and QoL scores were measured. Results: Out of a total of 115 patients, 98 patients completed the study. Before surgery, there was no significant difference between the two groups in prostate size (Prostate size was 54.52 ± 7.3 g in group A and 50.19 ± 6.8 g in group B, p value = 0.72), IPSS (19.86 ± 4.68 in group A vs. 21.14 ± 4.33 in group B, p value = 0.17), maximum urinary flow rate and post-void residual urine test results. No significant difference between Qol score in both groups before surgery (p value = 0.96). Group A patients had significantly less intraoperative blood loss than group B patients (308.29 ± 48.1 ml vs. 431.11 ± 96.4 ml, p = 0.001). One month postoperatively, group A patients showed greater improvement in QoL than group B patients (p = 0.03). Conclusions: Finasteride therapy for 6 weeks before TURP reduced intraoperative blood loss and statistically improved quality of life in the early postoperative period. However, larger number of patients and longer duration of follow up is recommended to confirm its clinical significance. Keywords: Finasteride, TURP, Quality of lifehttp://www.sciencedirect.com/science/article/pii/S1110570418300547 |
| spellingShingle | A.I. Ali A.M. Fawzy E. Ramadan M.M. El-Hawy T.K. Fathelbab A. Hussein M. Abd Elmalek Hassan L. Alshara E.R. Tawfiek Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? African Journal of Urology |
| title | Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? |
| title_full | Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? |
| title_fullStr | Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? |
| title_full_unstemmed | Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? |
| title_short | Six weeks finasteride monotherapy before TURP: Does it improve quality of life in early post operative period? |
| title_sort | six weeks finasteride monotherapy before turp does it improve quality of life in early post operative period |
| url | http://www.sciencedirect.com/science/article/pii/S1110570418300547 |
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