Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis
Growing resistance of microorganisms to antibiotics for the treatment of late-onset sepsis (LOS) in premature infants has led physicians to use antibiotics that are not well studied in neonatal populations. We aimed to determine the efficacy and safety of colistin and fluoroquinolone for the treatme...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016421001419 |
| _version_ | 1818918200271699968 |
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| author | Mountasser Al-Mouqdad Khalid Eljaaly Ayman Abdalgader Maha Al-Anazi Muhammed Taha Arwa Alshaibani Raneem Asfour Thanaa Khalil Suzan Asfour |
| author_facet | Mountasser Al-Mouqdad Khalid Eljaaly Ayman Abdalgader Maha Al-Anazi Muhammed Taha Arwa Alshaibani Raneem Asfour Thanaa Khalil Suzan Asfour |
| author_sort | Mountasser Al-Mouqdad |
| collection | DOAJ |
| description | Growing resistance of microorganisms to antibiotics for the treatment of late-onset sepsis (LOS) in premature infants has led physicians to use antibiotics that are not well studied in neonatal populations. We aimed to determine the efficacy and safety of colistin and fluoroquinolone for the treatment of persistent LOS. We retrospectively reviewed infants with gram-negative LOS, who received either colistin or fluoroquinolone therapy, to determine if there was a significant difference in kidney and liver function tests and electrolyte levels before, during, and at the end of the treatment. Infants who received colistin and fluoroquinolone had 17 and 34 positive cultures with gram-negative organisms, respectively. Multi-drug resistant organisms were more common in infants who received colistin than in those who received fluoroquinolone. Microbiological clearance was found to be higher in infants treated with fluoroquinolone than in those treated with colistin. In both the groups, the median levels of kidney and liver function tests and electrolytes showed a significant increase during the treatment. The prescription of colistin and fluoroquinolones should be reserved for cases with no other safe and effective alternatives. |
| first_indexed | 2024-12-20T00:46:11Z |
| format | Article |
| id | doaj.art-506af99bfb604ff8a36e4be6aca7cbbc |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-12-20T00:46:11Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-506af99bfb604ff8a36e4be6aca7cbbc2022-12-21T19:59:23ZengElsevierSaudi Pharmaceutical Journal1319-01642021-09-0129910131020Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsisMountasser Al-Mouqdad0Khalid Eljaaly1Ayman Abdalgader2Maha Al-Anazi3Muhammed Taha4Arwa Alshaibani5Raneem Asfour6Thanaa Khalil7Suzan Asfour8Neonatal Intensive Care Unit, Hospital of Paediatrics, King Saud Medical City, Riyadh, Saudi Arabia; Corresponding author at: Neonatal Intensive Care Unit, Hospital of Paediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh 12746, Saudi Arabia.Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaNeonatal Intensive Care Unit, Hospital of Paediatrics, King Saud Medical City, Riyadh, Saudi ArabiaPharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi ArabiaPharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi ArabiaGeneral Paediatrics Department, Hospital of Paediatrics, King Saud Medical City, Riyadh, Saudi ArabiaPharmacy College, Jordan University of Science and Technology, Irbid, JordanObstetrics and Gynecology Department, Maternity Hospital, King Saud Medical City, Riyadh, Saudi ArabiaClinical Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi ArabiaGrowing resistance of microorganisms to antibiotics for the treatment of late-onset sepsis (LOS) in premature infants has led physicians to use antibiotics that are not well studied in neonatal populations. We aimed to determine the efficacy and safety of colistin and fluoroquinolone for the treatment of persistent LOS. We retrospectively reviewed infants with gram-negative LOS, who received either colistin or fluoroquinolone therapy, to determine if there was a significant difference in kidney and liver function tests and electrolyte levels before, during, and at the end of the treatment. Infants who received colistin and fluoroquinolone had 17 and 34 positive cultures with gram-negative organisms, respectively. Multi-drug resistant organisms were more common in infants who received colistin than in those who received fluoroquinolone. Microbiological clearance was found to be higher in infants treated with fluoroquinolone than in those treated with colistin. In both the groups, the median levels of kidney and liver function tests and electrolytes showed a significant increase during the treatment. The prescription of colistin and fluoroquinolones should be reserved for cases with no other safe and effective alternatives.http://www.sciencedirect.com/science/article/pii/S1319016421001419Multi-drug resistant organismsAntibioticsColistinFluoroquinolonePremature infantsLate-onset sepsis |
| spellingShingle | Mountasser Al-Mouqdad Khalid Eljaaly Ayman Abdalgader Maha Al-Anazi Muhammed Taha Arwa Alshaibani Raneem Asfour Thanaa Khalil Suzan Asfour Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis Saudi Pharmaceutical Journal Multi-drug resistant organisms Antibiotics Colistin Fluoroquinolone Premature infants Late-onset sepsis |
| title | Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis |
| title_full | Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis |
| title_fullStr | Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis |
| title_full_unstemmed | Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis |
| title_short | Safety and efficacy of colistin and fluoroquinolone in neonatal persistent late-onset sepsis |
| title_sort | safety and efficacy of colistin and fluoroquinolone in neonatal persistent late onset sepsis |
| topic | Multi-drug resistant organisms Antibiotics Colistin Fluoroquinolone Premature infants Late-onset sepsis |
| url | http://www.sciencedirect.com/science/article/pii/S1319016421001419 |
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