Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor
Objective: To report a case of long-term disease free and successful pregnancy after fertility sparing staging surgery with adjuvant chemotherapy in a 46,Xy gonadal dysgenetic with malignant germ cell tumor. Materials and methods: A case report from a university hospital about a 19-year-old female w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2012-06-01
|
| Series: | Journal of Family and Reproductive Health |
| Subjects: | |
| Online Access: | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/149 |
| _version_ | 1811189520310206464 |
|---|---|
| author | Azamsadat Mousavi Mitra Gilani Shirin Goodarzi Ensieh Tehraninejad Hayedeh Haeri |
| author_facet | Azamsadat Mousavi Mitra Gilani Shirin Goodarzi Ensieh Tehraninejad Hayedeh Haeri |
| author_sort | Azamsadat Mousavi |
| collection | DOAJ |
| description | Objective: To report a case of long-term disease free and successful pregnancy after fertility sparing staging surgery with adjuvant chemotherapy in a 46,Xy gonadal dysgenetic with malignant germ cell tumor.
Materials and methods: A case report from a university hospital about a 19-year-old female with 46,XY karyotype ( Swyer syndrome). The patient underwent bilateral gonadectomy and staging with uterus preservation. Six course adjuvant chemotherapy with VBP (Vinblastin, Bleomycin, Cisplatin) was given. The case got pregnant through IVF- embryo donation. Disease free period and successful pregnancy is reported.
Results: After treatment the patient is free of the disease after 11 years follow-up. She underwent in vitro fertilization treatment with oocyte donation and gave birth to a healthy ch.
Conclusion: Improved multimodality treatment, allowance for consideration of fertility options for some women with gynecologic cancers. Since major concern in women with XY gonadal dysgenesis is ovarian malignancy, even with stage II dysgerminoma hysterectomy may not be required in some cases considering the opportunity for childbearing with the use of embryo transfer. |
| first_indexed | 2024-04-11T14:36:13Z |
| format | Article |
| id | doaj.art-506bd215e1194ae182de79772779c34f |
| institution | Directory Open Access Journal |
| issn | 1735-8949 1735-9392 |
| language | English |
| last_indexed | 2024-04-11T14:36:13Z |
| publishDate | 2012-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Family and Reproductive Health |
| spelling | doaj.art-506bd215e1194ae182de79772779c34f2022-12-22T04:18:19ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922012-06-0162149Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell TumorAzamsadat Mousavi0Mitra Gilani1Shirin Goodarzi2Ensieh Tehraninejad3Hayedeh Haeri4Department of gynecologic oncology, Tehran University of Medical Sciences, Tehran, Iran.Department of gynecologic oncology, Tehran University of Medical Sciences, Tehran, Iran.Department of gynecologic oncology, Tehran University of Medical Sciences, Tehran, Iran.Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of pathology, Imam Hospital, Tehran University of Medical Science, Tehran, IranObjective: To report a case of long-term disease free and successful pregnancy after fertility sparing staging surgery with adjuvant chemotherapy in a 46,Xy gonadal dysgenetic with malignant germ cell tumor. Materials and methods: A case report from a university hospital about a 19-year-old female with 46,XY karyotype ( Swyer syndrome). The patient underwent bilateral gonadectomy and staging with uterus preservation. Six course adjuvant chemotherapy with VBP (Vinblastin, Bleomycin, Cisplatin) was given. The case got pregnant through IVF- embryo donation. Disease free period and successful pregnancy is reported. Results: After treatment the patient is free of the disease after 11 years follow-up. She underwent in vitro fertilization treatment with oocyte donation and gave birth to a healthy ch. Conclusion: Improved multimodality treatment, allowance for consideration of fertility options for some women with gynecologic cancers. Since major concern in women with XY gonadal dysgenesis is ovarian malignancy, even with stage II dysgerminoma hysterectomy may not be required in some cases considering the opportunity for childbearing with the use of embryo transfer.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/149gonadal dysgenesisdysgerminomaadjuvant chemotherapysuccessful pregnancy |
| spellingShingle | Azamsadat Mousavi Mitra Gilani Shirin Goodarzi Ensieh Tehraninejad Hayedeh Haeri Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor Journal of Family and Reproductive Health gonadal dysgenesis dysgerminoma adjuvant chemotherapy successful pregnancy |
| title | Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor |
| title_full | Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor |
| title_fullStr | Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor |
| title_full_unstemmed | Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor |
| title_short | Long-term Disease Free and Successful Pregnancy in a Woman with Gonadal Dysgenesis and Malignant Germ Cell Tumor |
| title_sort | long term disease free and successful pregnancy in a woman with gonadal dysgenesis and malignant germ cell tumor |
| topic | gonadal dysgenesis dysgerminoma adjuvant chemotherapy successful pregnancy |
| url | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/149 |
| work_keys_str_mv | AT azamsadatmousavi longtermdiseasefreeandsuccessfulpregnancyinawomanwithgonadaldysgenesisandmalignantgermcelltumor AT mitragilani longtermdiseasefreeandsuccessfulpregnancyinawomanwithgonadaldysgenesisandmalignantgermcelltumor AT shiringoodarzi longtermdiseasefreeandsuccessfulpregnancyinawomanwithgonadaldysgenesisandmalignantgermcelltumor AT ensiehtehraninejad longtermdiseasefreeandsuccessfulpregnancyinawomanwithgonadaldysgenesisandmalignantgermcelltumor AT hayedehhaeri longtermdiseasefreeandsuccessfulpregnancyinawomanwithgonadaldysgenesisandmalignantgermcelltumor |