G721-0282 Exerts Anxiolytic-Like Effects on Chronic Unpredictable Mild Stress in Mice Through Inhibition of Chitinase-3-Like 1-Mediated Neuroinflammation

G721-0282 Exerts Anxiolytic-Like Effects on Chronic Unpredictable Mild Stress in Mice Through Inhibition of Chitinase-3-Like 1-Mediated Neuroinflammation

Chronic stress is thought to be a major contributor to the onset of mental disorders such as anxiety disorders. Several studies have demonstrated a correlation between anxiety state and neuroinflammation, but the detailed mechanism is unclear. Chitinase-3-like 1 (CHI3L1) is expressed in several chro...

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Bibliographic Details
Main Authors: Hyeon Joo Ham, Yong Sun Lee, Hee Pom Lee, Young Wan Ham, Jaesuk Yun, Sang Bae Han, Jin Tae Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
chronic unpredictabe mild stress
neuroinflammation
chitinase-3-like 1
IGFBP3
microglia activation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.793835/full

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