Central nervous system metastases in breast cancer patients with germline BRCA pathogenic variants compared to non-carriers: a matched-pair analysis

Central nervous system metastases in breast cancer patients with germline BRCA pathogenic variants compared to non-carriers: a matched-pair analysis

Abstract Background Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic risk factor for breast cancer, associated with poor prognostic factors....

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Bibliographic Details
Main Authors: Matan Ben-Zion Berliner, Shlomit Yust-Katz, Inbar Lavie, Yael Goldberg, Inbal Kedar, Rinat Yerushalmi
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Breast cancer
Central nervous system (CNS) metastasis
BRCA mutation
Leptomeningeal metastasis
Online Access:https://doi.org/10.1186/s12885-024-11975-7

Internet

https://doi.org/10.1186/s12885-024-11975-7

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