The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
Abstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-017-0021-9 |
| _version_ | 1797426716582346752 |
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| author | Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft |
| author_facet | Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft |
| author_sort | Louise Birkedal Glenthøj |
| collection | DOAJ |
| description | Abstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional improvements. This study systematically reviewed the evidence on the effectiveness of cognitive remediation in the ultra-high risk population. The electronic databases MEDLINE, PsycINFO, and Embase were searched using keywords related to cognitive remediation and the UHR state. Studies were included if they were peer-reviewed, written in English, and included a population meeting standardized ultra-high risk criteria. Six original research articles were identified. All the studies provided computerized, bottom-up-based cognitive remediation, predominantly targeting neurocognitive function. Four out of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence indicates an effect of cognitive remediation on cognition and functioning in ultra-high risk individuals. More research on cognitive remediation in ultra-high risk is needed, notably in large-scale trials assessing the effect of neurocognitive and/or social cognitive remediation on multiple outcomes. |
| first_indexed | 2024-03-09T08:33:48Z |
| format | Article |
| id | doaj.art-506dd8648f5b4590818a95b495507bf8 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T08:33:48Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-506dd8648f5b4590818a95b495507bf82023-12-02T18:47:09ZengNature Portfolionpj Schizophrenia2334-265X2017-05-01311810.1038/s41537-017-0021-9The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic reviewLouise Birkedal Glenthøj0Carsten Hjorthøj1Tina Dam KristensenCharlie Andrew Davidson2Merete Nordentoft3Mental Health Centre Copenhagen, Copenhagen University HospitalMental Health Centre Copenhagen, Copenhagen University HospitalDepartment of Psychiatry, Yale University School of MedicineMental Health Centre Copenhagen, Copenhagen University HospitalAbstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional improvements. This study systematically reviewed the evidence on the effectiveness of cognitive remediation in the ultra-high risk population. The electronic databases MEDLINE, PsycINFO, and Embase were searched using keywords related to cognitive remediation and the UHR state. Studies were included if they were peer-reviewed, written in English, and included a population meeting standardized ultra-high risk criteria. Six original research articles were identified. All the studies provided computerized, bottom-up-based cognitive remediation, predominantly targeting neurocognitive function. Four out of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence indicates an effect of cognitive remediation on cognition and functioning in ultra-high risk individuals. More research on cognitive remediation in ultra-high risk is needed, notably in large-scale trials assessing the effect of neurocognitive and/or social cognitive remediation on multiple outcomes.https://doi.org/10.1038/s41537-017-0021-9 |
| spellingShingle | Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review npj Schizophrenia |
| title | The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review |
| title_full | The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review |
| title_fullStr | The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review |
| title_full_unstemmed | The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review |
| title_short | The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review |
| title_sort | effect of cognitive remediation in individuals at ultra high risk for psychosis a systematic review |
| url | https://doi.org/10.1038/s41537-017-0021-9 |
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