Metabolomic Fingerprint of Mecp2-Deficient Mouse Cortex: Evidence for a Pronounced Multi-Facetted Metabolic Component in Rett Syndrome

Metabolomic Fingerprint of Mecp2-Deficient Mouse Cortex: Evidence for a Pronounced Multi-Facetted Metabolic Component in Rett Syndrome

Using unsupervised metabolomics, we defined the complex metabolic conditions in the cortex of a mouse model of Rett syndrome (RTT). RTT, which represents a cause of mental and cognitive disabilities in females, results in profound cognitive impairment with autistic features, motor disabilities, seiz...

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Bibliographic Details
Main Authors: Gocha Golubiani, Vincenzo Lagani, Revaz Solomonia, Michael Müller
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
Rett syndrome
Mecp2
pathogenic mechanism
metabolism
carbohydrates
amino acids
Online Access:https://www.mdpi.com/2073-4409/10/9/2494

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