Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix through protease recruitment and enhances cell adhesion, migration and signaling...

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Bibliographic Details
Main Authors: Michiel van Veen, Elisa Matas-Rico, Koen van de Wetering, Daniela Leyton-Puig, Katarzyna M Kedziora, Valentina De Lorenzi, Yvette Stijf-Bultsma, Bram van den Broek, Kees Jalink, Nicolai Sidenius, Anastassis Perrakis, Wouter H Moolenaar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
GDE3
glycerophosphodiester phosphodiesterase
glycosylphosphatidylinositol
signal transduction
Online Access:https://elifesciences.org/articles/23649

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