Does Vitamin D Level Affect Beta Cell Activity?
Objective:The prevalence of vitamin D deficiency is ever-increasing throughout the world. Vitamin D deficiency is associated with disorders such as diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. This research study was carried out to assess serum vitamin D levels of patients...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-12-01
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| Series: | Bagcilar Medical Bulletin |
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| Online Access: |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/does-vitamin-d-level-affect-beta-cell-activity/49738
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| _version_ | 1797919850426793984 |
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| author | Gülin Öztürk Özkan |
| author_facet | Gülin Öztürk Özkan |
| author_sort | Gülin Öztürk Özkan |
| collection | DOAJ |
| description | Objective:The prevalence of vitamin D deficiency is ever-increasing throughout the world. Vitamin D deficiency is associated with disorders such as diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. This research study was carried out to assess serum vitamin D levels of patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose.Method:This study was carried out on 504 patients, who were newly diagnosed and did not receive medication before, aged 18 to 80 years, and who had type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Their fasting glucose, fasting insulin, total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein-cholesterol, triglyceride, 25(OH)D concentration, height and body weight measurements were analyzed retrospectively. Body mass index, homeostatic model assessment (HOMA) for insulin resistance and HOMA beta (B) values of the patients were calculated.Results:It was found that 89.9% of the patients with type 2 diabetes, 90.6% of the insulin resistance patients, 91.7% of the obesity patients and 94.1% of the impaired fast glucose patients had less than 30 ng/mL of serum 25(OH)D concentration. It was seen that the serum 25(OH)D concentrations of the patients were negatively correlated with their fasting insulin concentrations and HOMA B values, and positively correlated with their HDL-cholesterol levels.Conclusion:Based on this study, vitamin D deficiency was found to be common in the patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Serum 25(OH)D concentrations were correlated with the levels of fasting insulin, HDL-cholesterol, and beta-cell function. |
| first_indexed | 2024-04-10T13:52:00Z |
| format | Article |
| id | doaj.art-50722cf806f2447cb62d65f49acc321b |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T13:52:00Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-50722cf806f2447cb62d65f49acc321b2023-02-15T16:10:39ZengGalenos YayineviBagcilar Medical Bulletin2547-94312021-12-016439740610.4274/BMB.galenos.2021.03.03813049054Does Vitamin D Level Affect Beta Cell Activity?Gülin Öztürk Özkan0 İstanbul Medeniyet University Faculty of Health Sciences, Department of Nutrition and Dietetics, İstanbul, Turkey Objective:The prevalence of vitamin D deficiency is ever-increasing throughout the world. Vitamin D deficiency is associated with disorders such as diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. This research study was carried out to assess serum vitamin D levels of patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose.Method:This study was carried out on 504 patients, who were newly diagnosed and did not receive medication before, aged 18 to 80 years, and who had type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Their fasting glucose, fasting insulin, total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein-cholesterol, triglyceride, 25(OH)D concentration, height and body weight measurements were analyzed retrospectively. Body mass index, homeostatic model assessment (HOMA) for insulin resistance and HOMA beta (B) values of the patients were calculated.Results:It was found that 89.9% of the patients with type 2 diabetes, 90.6% of the insulin resistance patients, 91.7% of the obesity patients and 94.1% of the impaired fast glucose patients had less than 30 ng/mL of serum 25(OH)D concentration. It was seen that the serum 25(OH)D concentrations of the patients were negatively correlated with their fasting insulin concentrations and HOMA B values, and positively correlated with their HDL-cholesterol levels.Conclusion:Based on this study, vitamin D deficiency was found to be common in the patients with type 2 diabetes, insulin resistance, obesity, and impaired fasting glucose. Serum 25(OH)D concentrations were correlated with the levels of fasting insulin, HDL-cholesterol, and beta-cell function. http://behmedicalbulletin.org/archives/archive-detail/article-preview/does-vitamin-d-level-affect-beta-cell-activity/49738 homa bhoma-irinsulin resistanceobesitytype 2 diabetesvitamin d |
| spellingShingle | Gülin Öztürk Özkan Does Vitamin D Level Affect Beta Cell Activity? Bagcilar Medical Bulletin homa b homa-ir insulin resistance obesity type 2 diabetes vitamin d |
| title | Does Vitamin D Level Affect Beta Cell Activity? |
| title_full | Does Vitamin D Level Affect Beta Cell Activity? |
| title_fullStr | Does Vitamin D Level Affect Beta Cell Activity? |
| title_full_unstemmed | Does Vitamin D Level Affect Beta Cell Activity? |
| title_short | Does Vitamin D Level Affect Beta Cell Activity? |
| title_sort | does vitamin d level affect beta cell activity |
| topic | homa b homa-ir insulin resistance obesity type 2 diabetes vitamin d |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/does-vitamin-d-level-affect-beta-cell-activity/49738
|
| work_keys_str_mv | AT gulinozturkozkan doesvitamindlevelaffectbetacellactivity |