Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic
BackgroundDirect acting antiretrovirals (DAA) are effective for individuals who are infected with chronic hepatitis C virus (HCV), yet many people go without access to these lifesaving treatments.Materials and methodsWe conducted a non-randomized study evaluating treatment data for patients in outpa...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.932306/full |
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| author | Phyllis Losikoff Phyllis Losikoff Jordon D. Bosse Jordon D. Bosse Stephen A. Martin Stephen A. Martin Amanda Wilson Lisa M. Chiodo Lisa M. Chiodo |
| author_facet | Phyllis Losikoff Phyllis Losikoff Jordon D. Bosse Jordon D. Bosse Stephen A. Martin Stephen A. Martin Amanda Wilson Lisa M. Chiodo Lisa M. Chiodo |
| author_sort | Phyllis Losikoff |
| collection | DOAJ |
| description | BackgroundDirect acting antiretrovirals (DAA) are effective for individuals who are infected with chronic hepatitis C virus (HCV), yet many people go without access to these lifesaving treatments.Materials and methodsWe conducted a non-randomized study evaluating treatment data for patients in outpatient treatment for opioid use disorder (OUD) at a private clinic. Patients who were HCV-positive, had been in OUD treatment for at least 4 weeks, and engaged in integrated HCV treatment with DAA (co-located within their treatment for OUD) were compared to patients with HCV who only received OUD treatment. We evaluated HCV cure; OUD medication adherence, treatment utilization and retention; and illicit substance use for those engaged in treatment between 9/2016 and 1/2018.ResultsSeventy-four patients completed integrated HCV-OUD treatment with DAA, with 87.8% achieving cure. Of the 66 who completed treatment and were subsequently evaluated for sustained viral response 98.5% were cured. Patients who received integrated HCV and OUD treatment in our clinic, stayed in OUD treatment longer, demonstrated higher OUD medication adherence, and used less opioids or cocaine compared to HCV-infected patients (n = 572) being treated only for OUD.DiscussionWe have reported on a reproducible intervention that lends itself to outpatient OUD treatment. Analyses demonstrate the potential positive impact HCV treatment has on OUD recovery, including reduction in opioid and cocaine use and increased retention in careConclusionCo-locating HCV treatment with existing OUD treatment is feasible, effective, and demonstrates positive outcomes for the treatment of both conditions. |
| first_indexed | 2024-04-11T20:29:08Z |
| format | Article |
| id | doaj.art-507528affde641a29ebc16a47477aa0d |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T20:29:08Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-507528affde641a29ebc16a47477aa0d2022-12-22T04:04:33ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-09-011310.3389/fpsyt.2022.932306932306Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinicPhyllis Losikoff0Phyllis Losikoff1Jordon D. Bosse2Jordon D. Bosse3Stephen A. Martin4Stephen A. Martin5Amanda Wilson6Lisa M. Chiodo7Lisa M. Chiodo8CleanSlate Outpatient Addiction Medicine, New Bedford, MA, United StatesDivision of Pediatric Infectious Disease, The Warren Alpert Medical School of Brown University, Providence, RI, United StatesSchool of Nursing, Bouvè College of Health Sciences, Northeastern University, Boston, MA, United StatesMassachusetts General Hospital, Boston, MA, United StatesBarre Family Health Center, Barre, MA, United StatesDepartment of Family Medicine and Community Health, UMass Chan Medical School, Worcester, MA, United StatesAddiction Research and Education Foundation, Gig Harbor, WA, United StatesAddiction Research and Education Foundation, Gig Harbor, WA, United StatesElaine Marieb College of Nursing, University of Massachusetts, Amherst, MA, United StatesBackgroundDirect acting antiretrovirals (DAA) are effective for individuals who are infected with chronic hepatitis C virus (HCV), yet many people go without access to these lifesaving treatments.Materials and methodsWe conducted a non-randomized study evaluating treatment data for patients in outpatient treatment for opioid use disorder (OUD) at a private clinic. Patients who were HCV-positive, had been in OUD treatment for at least 4 weeks, and engaged in integrated HCV treatment with DAA (co-located within their treatment for OUD) were compared to patients with HCV who only received OUD treatment. We evaluated HCV cure; OUD medication adherence, treatment utilization and retention; and illicit substance use for those engaged in treatment between 9/2016 and 1/2018.ResultsSeventy-four patients completed integrated HCV-OUD treatment with DAA, with 87.8% achieving cure. Of the 66 who completed treatment and were subsequently evaluated for sustained viral response 98.5% were cured. Patients who received integrated HCV and OUD treatment in our clinic, stayed in OUD treatment longer, demonstrated higher OUD medication adherence, and used less opioids or cocaine compared to HCV-infected patients (n = 572) being treated only for OUD.DiscussionWe have reported on a reproducible intervention that lends itself to outpatient OUD treatment. Analyses demonstrate the potential positive impact HCV treatment has on OUD recovery, including reduction in opioid and cocaine use and increased retention in careConclusionCo-locating HCV treatment with existing OUD treatment is feasible, effective, and demonstrates positive outcomes for the treatment of both conditions.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.932306/fullhepatitis C infectionopioid use disorderdirect acting antiretroviralsintegrated careaddiction medicine |
| spellingShingle | Phyllis Losikoff Phyllis Losikoff Jordon D. Bosse Jordon D. Bosse Stephen A. Martin Stephen A. Martin Amanda Wilson Lisa M. Chiodo Lisa M. Chiodo Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic Frontiers in Psychiatry hepatitis C infection opioid use disorder direct acting antiretrovirals integrated care addiction medicine |
| title | Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| title_full | Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| title_fullStr | Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| title_full_unstemmed | Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| title_short | Integrated hepatitis C treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| title_sort | integrated hepatitis c treatment is associated with improved retention and success in outpatient treatment for opioid use disorder at a private clinic |
| topic | hepatitis C infection opioid use disorder direct acting antiretrovirals integrated care addiction medicine |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.932306/full |
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