Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review
Among various polysaccharides, alginate-based nanostructures have etched an indelible mark on the canvas of biomolecules’ delivery. Although several review articles on the use of alginates for the delivery of drugs and other bio-active agents can be retrieved from various literature repositories, ho...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923001238 |
| _version_ | 1797377834766827520 |
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| author | Rocktotpal Konwarh Anand Pratap Singh Vijayakumar Varadarajan William C. Cho |
| author_facet | Rocktotpal Konwarh Anand Pratap Singh Vijayakumar Varadarajan William C. Cho |
| author_sort | Rocktotpal Konwarh |
| collection | DOAJ |
| description | Among various polysaccharides, alginate-based nanostructures have etched an indelible mark on the canvas of biomolecules’ delivery. Although several review articles on the use of alginates for the delivery of drugs and other bio-active agents can be retrieved from various literature repositories, however, the progress in the realm of alginate-based nanomaterials and its nanocomposites for nucleic acid/gene delivery has not been specifically reviewed of late. In this context, the write up in this article is geared off with highlights on alginate's structure-bioactivity concert, molecular modulations, and brief description about the different approaches to fabricate its various nanostructures. The subsequent section is then specifically streamlined towards comprehending the formulation, the biophysicochemical features and applications of alginate-based nanomaterials and nanocomposites for nucleic acid/ gene delivery applications to address various biomedical issues, as attested by a couple of topical investigations. Representative studies on gene delivery using alginate-based nanobiomaterials in research pertaining to cancer therapy, macrophage targeting and repolarization, intestine-inflammation targeting, bone regeneration, autosomal dominant polycystic kidney disease therapy and wound healing therapy, amongst others are presented. Various practical snags and prospective future direction of research in the use of alginate based nanobiomaterials for gene therapy are highlighted in the concluding section. |
| first_indexed | 2024-03-08T19:58:01Z |
| format | Article |
| id | doaj.art-50771c4c05d744a9abd87b783708b809 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T19:58:01Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-50771c4c05d744a9abd87b783708b8092023-12-24T04:46:56ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-06-017100404Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive reviewRocktotpal Konwarh0Anand Pratap Singh1Vijayakumar Varadarajan2William C. Cho3Department of Biotechnology, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Akaki Kality, Addis Ababa, 16417, Ethiopia; Corresponding authors.Baba Kinaram Research Foundation, Awadh Vatika, 769/1 A, Brahmsthan, Sahadatpura, Mau, Uttar Pradesh, 275101, India; Center for Multidisciplinary Research, Tezpur University, Napaam, Sonitpur, Assam, 784028, IndiaResearch Division, Swiss School of Business Management, 1213 Geneva, Switzerland; NUOVOS, Ajeenkya D Y Patil University, Pune, Maharashtra, 412105, IndiaDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, SAR, China; Corresponding authors.Among various polysaccharides, alginate-based nanostructures have etched an indelible mark on the canvas of biomolecules’ delivery. Although several review articles on the use of alginates for the delivery of drugs and other bio-active agents can be retrieved from various literature repositories, however, the progress in the realm of alginate-based nanomaterials and its nanocomposites for nucleic acid/gene delivery has not been specifically reviewed of late. In this context, the write up in this article is geared off with highlights on alginate's structure-bioactivity concert, molecular modulations, and brief description about the different approaches to fabricate its various nanostructures. The subsequent section is then specifically streamlined towards comprehending the formulation, the biophysicochemical features and applications of alginate-based nanomaterials and nanocomposites for nucleic acid/ gene delivery applications to address various biomedical issues, as attested by a couple of topical investigations. Representative studies on gene delivery using alginate-based nanobiomaterials in research pertaining to cancer therapy, macrophage targeting and repolarization, intestine-inflammation targeting, bone regeneration, autosomal dominant polycystic kidney disease therapy and wound healing therapy, amongst others are presented. Various practical snags and prospective future direction of research in the use of alginate based nanobiomaterials for gene therapy are highlighted in the concluding section.http://www.sciencedirect.com/science/article/pii/S2666893923001238AlginateNanocompositeNucleic acid deliveryGene therapyNanomedicine |
| spellingShingle | Rocktotpal Konwarh Anand Pratap Singh Vijayakumar Varadarajan William C. Cho Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review Carbohydrate Polymer Technologies and Applications Alginate Nanocomposite Nucleic acid delivery Gene therapy Nanomedicine |
| title | Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review |
| title_full | Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review |
| title_fullStr | Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review |
| title_full_unstemmed | Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review |
| title_short | Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review |
| title_sort | harnessing alginate based nanocomposites as nucleic acid gene delivery platforms to address diverse biomedical issues a progressive review |
| topic | Alginate Nanocomposite Nucleic acid delivery Gene therapy Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923001238 |
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