Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus–infected mice

Antiviral immunity often requires CD8+ cytotoxic T lymphocytes (CTLs) that actively migrate and search for virus-infected targets. Regulatory T cells (Tregs) have been shown to suppress CTL responses, but it is not known whether this is also mediated by effects on CTL motility. Here, we used intravi...

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Bibliographic Details
Main Authors: Daniela Mittermüller, Lucas Otto, Zoë Long, Andreas Kraus, Alexander Beer, Anja Hasenberg, Gennadiy Zelinskyy, Jaana Westmeier, Kim J. Hasenkrug, Ulf Dittmer, Matthias Gunzer
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.167482

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