ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
ABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Coluna (SBC)
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| Series: | Coluna/Columna |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237&lng=en&tlng=en |
| _version_ | 1811251720530952192 |
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| author | Liudmila Andreevna Bardonova Omar Sheikh Irina Olegovna Malova Vladimir Alexeevich Sorokovikov Vadim Anatolyevich Byvaltsev |
| author_facet | Liudmila Andreevna Bardonova Omar Sheikh Irina Olegovna Malova Vladimir Alexeevich Sorokovikov Vadim Anatolyevich Byvaltsev |
| author_sort | Liudmila Andreevna Bardonova |
| collection | DOAJ |
| description | ABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment. |
| first_indexed | 2024-04-12T16:24:34Z |
| format | Article |
| id | doaj.art-5077a0dfbf1e40cd9d1bce373e753fe3 |
| institution | Directory Open Access Journal |
| issn | 2177-014X |
| language | English |
| last_indexed | 2024-04-12T16:24:34Z |
| publisher | Sociedade Brasileira de Coluna (SBC) |
| record_format | Article |
| series | Coluna/Columna |
| spelling | doaj.art-5077a0dfbf1e40cd9d1bce373e753fe32022-12-22T03:25:25ZengSociedade Brasileira de Coluna (SBC)Coluna/Columna2177-014X17323723910.1590/s1808-185120181703193837S1808-18512018000300237ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISCLiudmila Andreevna BardonovaOmar SheikhIrina Olegovna MalovaVladimir Alexeevich SorokovikovVadim Anatolyevich ByvaltsevABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237&lng=en&tlng=enDisco intervertebralNúcleo pulposoAnel fibrosoMetabolismo energéticoTerapia celular |
| spellingShingle | Liudmila Andreevna Bardonova Omar Sheikh Irina Olegovna Malova Vladimir Alexeevich Sorokovikov Vadim Anatolyevich Byvaltsev ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC Coluna/Columna Disco intervertebral Núcleo pulposo Anel fibroso Metabolismo energético Terapia celular |
| title | ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC |
| title_full | ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC |
| title_fullStr | ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC |
| title_full_unstemmed | ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC |
| title_short | ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC |
| title_sort | energy supply and demand in the intervertebral disc |
| topic | Disco intervertebral Núcleo pulposo Anel fibroso Metabolismo energético Terapia celular |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237&lng=en&tlng=en |
| work_keys_str_mv | AT liudmilaandreevnabardonova energysupplyanddemandintheintervertebraldisc AT omarsheikh energysupplyanddemandintheintervertebraldisc AT irinaolegovnamalova energysupplyanddemandintheintervertebraldisc AT vladimiralexeevichsorokovikov energysupplyanddemandintheintervertebraldisc AT vadimanatolyevichbyvaltsev energysupplyanddemandintheintervertebraldisc |