Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential
Oxidative stress (OS) is detrimental to sperm functions, and the oxidation reduction potential (ORP) is a good measure of OS as it considers the balance between oxidants and reductants. Total motile sperm count (TMSC) is viewed as the single most important semen analysis parameter that can predict m...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=3;spage=317;epage=322;aulast= |
| _version_ | 1819153952349880320 |
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| author | Ahmad Majzoub Mohamed Arafa Walid El Ansari Mohammed Mahdi Ashok Agarwal Sami Al-Said Haitham Elbardisi |
| author_facet | Ahmad Majzoub Mohamed Arafa Walid El Ansari Mohammed Mahdi Ashok Agarwal Sami Al-Said Haitham Elbardisi |
| author_sort | Ahmad Majzoub |
| collection | DOAJ |
| description | Oxidative stress (OS) is detrimental to sperm functions, and the oxidation reduction potential (ORP) is a good measure of OS as it considers the balance between oxidants and reductants. Total motile sperm count (TMSC) is viewed as the single most important semen analysis parameter that can predict male infertility severity, and its correlation with ORP has never been undertaken. The objectives of this study were to assess the correlation between ORP and TMSC, to identify the ORP cutoff value based on the TMSC result, and to compare this cutoff value with previously reported ORP cutoff values in literature. One thousand one hundred and sixty-eight infertile patients and 100 fertile controls were enrolled. Demographic and semen data of the participants were retrieved and analyzed. Wilcoxon's rank-sum test compared variables between infertile men and fertile controls; Spearman's correlation assessed the static ORP (sORP)-TMSC relationship for the whole sample and among each group individually. Using a 20×106TMSC threshold, receiver operator characteristic (ROC) analysis determined the sORP cutoff associated with the highest predictive values. TMSC was significantly negatively correlated with sORP across all participants (r = 0.86, P < 0.001), among infertile patients (r = 0.729, P < 0.001), and among fertile controls (r = 0.53, P < 0.001). A 20-million TMSC threshold determined an sORP cutoff value of 2.34 mV/106sperm/ml to be associated with 82.9% sensitivity, 82.8% specificity, 91.5% positive predictive value (PPV), 68.5% negative predictive value (NPV), and 82.9% overall accuracy. Compared with previously reported cutoff values in searched literature, the 2.34 mV/106sperm/ml cutoff value identified in our study yielded the highest overall diagnostic accuracy in the evaluation of infertile men. |
| first_indexed | 2024-12-22T15:13:21Z |
| format | Article |
| id | doaj.art-507a5419aafb440db670deeb92bcbff6 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-22T15:13:21Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-507a5419aafb440db670deeb92bcbff62022-12-21T18:21:49ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622020-01-0122331732210.4103/aja.aja_75_19Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potentialAhmad MajzoubMohamed ArafaWalid El AnsariMohammed MahdiAshok AgarwalSami Al-SaidHaitham ElbardisiOxidative stress (OS) is detrimental to sperm functions, and the oxidation reduction potential (ORP) is a good measure of OS as it considers the balance between oxidants and reductants. Total motile sperm count (TMSC) is viewed as the single most important semen analysis parameter that can predict male infertility severity, and its correlation with ORP has never been undertaken. The objectives of this study were to assess the correlation between ORP and TMSC, to identify the ORP cutoff value based on the TMSC result, and to compare this cutoff value with previously reported ORP cutoff values in literature. One thousand one hundred and sixty-eight infertile patients and 100 fertile controls were enrolled. Demographic and semen data of the participants were retrieved and analyzed. Wilcoxon's rank-sum test compared variables between infertile men and fertile controls; Spearman's correlation assessed the static ORP (sORP)-TMSC relationship for the whole sample and among each group individually. Using a 20×106TMSC threshold, receiver operator characteristic (ROC) analysis determined the sORP cutoff associated with the highest predictive values. TMSC was significantly negatively correlated with sORP across all participants (r = 0.86, P < 0.001), among infertile patients (r = 0.729, P < 0.001), and among fertile controls (r = 0.53, P < 0.001). A 20-million TMSC threshold determined an sORP cutoff value of 2.34 mV/106sperm/ml to be associated with 82.9% sensitivity, 82.8% specificity, 91.5% positive predictive value (PPV), 68.5% negative predictive value (NPV), and 82.9% overall accuracy. Compared with previously reported cutoff values in searched literature, the 2.34 mV/106sperm/ml cutoff value identified in our study yielded the highest overall diagnostic accuracy in the evaluation of infertile men.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=3;spage=317;epage=322;aulast=male infertility; oxidation reduction potential; oxidative stress; total motile sperm |
| spellingShingle | Ahmad Majzoub Mohamed Arafa Walid El Ansari Mohammed Mahdi Ashok Agarwal Sami Al-Said Haitham Elbardisi Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential Asian Journal of Andrology male infertility; oxidation reduction potential; oxidative stress; total motile sperm |
| title | Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential |
| title_full | Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential |
| title_fullStr | Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential |
| title_full_unstemmed | Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential |
| title_short | Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential |
| title_sort | correlation of oxidation reduction potential and total motile sperm count its utility in the evaluation of male fertility potential |
| topic | male infertility; oxidation reduction potential; oxidative stress; total motile sperm |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=3;spage=317;epage=322;aulast= |
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