Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial
Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procu...
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Iranian Society of Pharmacognosy
2018-06-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | http://www.rjpharmacognosy.ir/article_64860_3f60b43d8238c9a451f59d5fa6d87dd9.pdf |
| _version_ | 1818928155248820224 |
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| author | Mehran Zarghami Aroona Chabra Mohammad Azadbakht* Alireza Khalilian Ali Asghar Hoseini |
| author_facet | Mehran Zarghami Aroona Chabra Mohammad Azadbakht* Alireza Khalilian Ali Asghar Hoseini |
| author_sort | Mehran Zarghami |
| collection | DOAJ |
| description | Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 30 outpatients with mild to moderate depressive disorder (according to DMS-IV-TR criteria who had a score of 18-25 on the Hamilton Depression Rating Scale (HDRS) were randomly divided in two group, 1) received 10 mg fluoxetine capsule, 2) received 1.2 g dried extract of A. procumbens capsule (6 mg flavonoid,) orally per day. Patients were followed up for 6 weeks; the recovery process was assessed by the HDRS in weeks 0, 2, 4 and 6. Results: A significant decrease in HDRS was observed in both groups after the fourth week. After the sixth week, fluoxetine had a greater anti-depressant activity than A. procumbens (p value =0.03). There were no significant differences in terms of adverse effects in both groups. Conclusions: The hydroalcoholic extract of A. procumbens can be considered as an effective and safe remedy for mild to moderate depressive disorder. |
| first_indexed | 2024-12-20T03:24:25Z |
| format | Article |
| id | doaj.art-507c0663638f43829ed0da88f50edfcd |
| institution | Directory Open Access Journal |
| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-12-20T03:24:25Z |
| publishDate | 2018-06-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-507c0663638f43829ed0da88f50edfcd2022-12-21T19:55:07ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772018-06-0153152010.22127/rjp.2018.6486064860Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical TrialMehran Zarghami0Aroona Chabra1Mohammad Azadbakht*2Alireza Khalilian3Ali Asghar Hoseini4Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.Department of Biostatistics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Psychiatry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 30 outpatients with mild to moderate depressive disorder (according to DMS-IV-TR criteria who had a score of 18-25 on the Hamilton Depression Rating Scale (HDRS) were randomly divided in two group, 1) received 10 mg fluoxetine capsule, 2) received 1.2 g dried extract of A. procumbens capsule (6 mg flavonoid,) orally per day. Patients were followed up for 6 weeks; the recovery process was assessed by the HDRS in weeks 0, 2, 4 and 6. Results: A significant decrease in HDRS was observed in both groups after the fourth week. After the sixth week, fluoxetine had a greater anti-depressant activity than A. procumbens (p value =0.03). There were no significant differences in terms of adverse effects in both groups. Conclusions: The hydroalcoholic extract of A. procumbens can be considered as an effective and safe remedy for mild to moderate depressive disorder.http://www.rjpharmacognosy.ir/article_64860_3f60b43d8238c9a451f59d5fa6d87dd9.pdfAsperugo procumbensbadranjbuyehDepressionfluoxetine |
| spellingShingle | Mehran Zarghami Aroona Chabra Mohammad Azadbakht* Alireza Khalilian Ali Asghar Hoseini Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial Research Journal of Pharmacognosy Asperugo procumbens badranjbuyeh Depression fluoxetine |
| title | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
| title_full | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
| title_fullStr | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
| title_full_unstemmed | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
| title_short | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
| title_sort | antidepressant effect of asperugo procumbens l in comparison with fluoxetine a randomized double blind clinical trial |
| topic | Asperugo procumbens badranjbuyeh Depression fluoxetine |
| url | http://www.rjpharmacognosy.ir/article_64860_3f60b43d8238c9a451f59d5fa6d87dd9.pdf |
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