Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06).
To determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings.Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median volume ratio and gen...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5354274?pdf=render |
| _version_ | 1828877674168188928 |
|---|---|
| author | Ji Hyeon Joo Young Seok Kim Byung Chul Cho Chi Young Jeong Won Park Hak Jae Kim Won Sup Yoon Mee Sun Yoon Ji-Yoon Kim Jin Hwa Choi Youngmin Choi Joo-Young Kim |
| author_facet | Ji Hyeon Joo Young Seok Kim Byung Chul Cho Chi Young Jeong Won Park Hak Jae Kim Won Sup Yoon Mee Sun Yoon Ji-Yoon Kim Jin Hwa Choi Youngmin Choi Joo-Young Kim |
| author_sort | Ji Hyeon Joo |
| collection | DOAJ |
| description | To determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings.Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median volume ratio and generalized conformity index (CIgen). And center of mass (COM) of each contour was calculated. Expert agreement was quantified using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE).For definitive RT, the individual/median volume ratio ranged from 0.51 to 1.41, and CIgen was 0.531. Mean 3-dimensional distances of average to each COM were 7.8 mm. For postoperative RT setting, corresponding values were 0.65-1.38, 0.563, and 5.3 mm. Kappa value of expert agreement was 0.65 and 0.67, respectively. STAPLE estimates of the sensitivity, specificity, and kappa measures of inter-physician agreement were 0.73, 0.98, and 0.65 for the definitive and 0.75, 0.98, and 0.67 for the adjuvant radiotherapy setting. The largest difference was observed in the superior-inferior direction, particularly in the upper vagina and the common iliac area.As there was still some variability in target delineation, more detailed guidelines for target volume delineation and continuing education would help to reduce this uncertainty. |
| first_indexed | 2024-12-13T08:49:07Z |
| format | Article |
| id | doaj.art-507d2533f55c41c7a049ea385faa6992 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T08:49:07Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-507d2533f55c41c7a049ea385faa69922022-12-21T23:53:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017347610.1371/journal.pone.0173476Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06).Ji Hyeon JooYoung Seok KimByung Chul ChoChi Young JeongWon ParkHak Jae KimWon Sup YoonMee Sun YoonJi-Yoon KimJin Hwa ChoiYoungmin ChoiJoo-Young KimTo determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings.Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median volume ratio and generalized conformity index (CIgen). And center of mass (COM) of each contour was calculated. Expert agreement was quantified using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE).For definitive RT, the individual/median volume ratio ranged from 0.51 to 1.41, and CIgen was 0.531. Mean 3-dimensional distances of average to each COM were 7.8 mm. For postoperative RT setting, corresponding values were 0.65-1.38, 0.563, and 5.3 mm. Kappa value of expert agreement was 0.65 and 0.67, respectively. STAPLE estimates of the sensitivity, specificity, and kappa measures of inter-physician agreement were 0.73, 0.98, and 0.65 for the definitive and 0.75, 0.98, and 0.67 for the adjuvant radiotherapy setting. The largest difference was observed in the superior-inferior direction, particularly in the upper vagina and the common iliac area.As there was still some variability in target delineation, more detailed guidelines for target volume delineation and continuing education would help to reduce this uncertainty.http://europepmc.org/articles/PMC5354274?pdf=render |
| spellingShingle | Ji Hyeon Joo Young Seok Kim Byung Chul Cho Chi Young Jeong Won Park Hak Jae Kim Won Sup Yoon Mee Sun Yoon Ji-Yoon Kim Jin Hwa Choi Youngmin Choi Joo-Young Kim Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). PLoS ONE |
| title | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). |
| title_full | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). |
| title_fullStr | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). |
| title_full_unstemmed | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). |
| title_short | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06). |
| title_sort | variability in target delineation of cervical carcinoma a korean radiation oncology group study krog 15 06 |
| url | http://europepmc.org/articles/PMC5354274?pdf=render |
| work_keys_str_mv | AT jihyeonjoo variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT youngseokkim variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT byungchulcho variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT chiyoungjeong variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT wonpark variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT hakjaekim variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT wonsupyoon variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT meesunyoon variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT jiyoonkim variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT jinhwachoi variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT youngminchoi variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 AT jooyoungkim variabilityintargetdelineationofcervicalcarcinomaakoreanradiationoncologygroupstudykrog1506 |