The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing
Recent advances in genomic sequencing technologies have expanded practitioners’ utilization of genetic information in a timely and efficient manner for an accurate diagnosis. With an ever-increasing resource of genomic data from progress in the interpretation of genome sequences, clinicians face dec...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | International Journal of Neonatal Screening |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2409-515X/8/2/36 |
| _version_ | 1797486292678737920 |
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| author | Calli O. Mitchell Greysha Rivera-Cruz Matthew Hoi Kin Chau Zirui Dong Kwong Wai Choy Jun Shen Sami Amr Anne B. S. Giersch Cynthia C. Morton |
| author_facet | Calli O. Mitchell Greysha Rivera-Cruz Matthew Hoi Kin Chau Zirui Dong Kwong Wai Choy Jun Shen Sami Amr Anne B. S. Giersch Cynthia C. Morton |
| author_sort | Calli O. Mitchell |
| collection | DOAJ |
| description | Recent advances in genomic sequencing technologies have expanded practitioners’ utilization of genetic information in a timely and efficient manner for an accurate diagnosis. With an ever-increasing resource of genomic data from progress in the interpretation of genome sequences, clinicians face decisions about how and when genomic information should be presented to families, and at what potential expense. Presently, there is limited knowledge or experience in establishing the value of implementing genome sequencing into newborn screening. Herein we provide insight into the complexities and the burden and benefits of knowledge resulting from genome sequencing of newborns. |
| first_indexed | 2024-03-09T23:31:07Z |
| format | Article |
| id | doaj.art-507ffb223c5746caba03c4aec6ea2a0c |
| institution | Directory Open Access Journal |
| issn | 2409-515X |
| language | English |
| last_indexed | 2024-03-09T23:31:07Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Neonatal Screening |
| spelling | doaj.art-507ffb223c5746caba03c4aec6ea2a0c2023-11-23T17:08:38ZengMDPI AGInternational Journal of Neonatal Screening2409-515X2022-05-01823610.3390/ijns8020036The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for HearingCalli O. Mitchell0Greysha Rivera-Cruz1Matthew Hoi Kin Chau2Zirui Dong3Kwong Wai Choy4Jun Shen5Sami Amr6Anne B. S. Giersch7Cynthia C. Morton8Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Pediatrics, Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA 02115, USADepartment of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, MA 02115, USARecent advances in genomic sequencing technologies have expanded practitioners’ utilization of genetic information in a timely and efficient manner for an accurate diagnosis. With an ever-increasing resource of genomic data from progress in the interpretation of genome sequences, clinicians face decisions about how and when genomic information should be presented to families, and at what potential expense. Presently, there is limited knowledge or experience in establishing the value of implementing genome sequencing into newborn screening. Herein we provide insight into the complexities and the burden and benefits of knowledge resulting from genome sequencing of newborns.https://www.mdpi.com/2409-515X/8/2/36genome sequencingnewborn hearing screeningnewborn screeningnewborn genome sequencingincidental findingssecondary findings |
| spellingShingle | Calli O. Mitchell Greysha Rivera-Cruz Matthew Hoi Kin Chau Zirui Dong Kwong Wai Choy Jun Shen Sami Amr Anne B. S. Giersch Cynthia C. Morton The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing International Journal of Neonatal Screening genome sequencing newborn hearing screening newborn screening newborn genome sequencing incidental findings secondary findings |
| title | The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing |
| title_full | The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing |
| title_fullStr | The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing |
| title_full_unstemmed | The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing |
| title_short | The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing |
| title_sort | burden and benefits of knowledge ethical considerations surrounding population based newborn genome screening for hearing |
| topic | genome sequencing newborn hearing screening newborn screening newborn genome sequencing incidental findings secondary findings |
| url | https://www.mdpi.com/2409-515X/8/2/36 |
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