Improved Multimodal Tumor Necrosis Imaging with IRDye800CW-DOTA Conjugated to an Albumin-Binding Domain

Improved Multimodal Tumor Necrosis Imaging with IRDye800CW-DOTA Conjugated to an Albumin-Binding Domain

Purpose: To assess our improved NACA for the detection of tumor necrosis. Methods: We increased the blood circulation time of our NACA by adding an albumin-binding domain to the molecular structure. We tested the necrosis avidity on dead or alive cultured cells and performed SPECT and fluorescence i...

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Bibliographic Details
Main Authors: Marcus C. M. Stroet, Erik de Blois, Marion de Jong, Yann Seimbille, Laura Mezzanotte, Clemens W. G. M. Löwik, Kranthi M. Panth
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
necrosis-avid contrast agent
cyanines
multimodal imaging
therapy efficacy
Online Access:https://www.mdpi.com/2072-6694/14/4/861

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