Herb-Induced Liver Injury—A Challenging Diagnosis
Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/10/2/278 |
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| author | David Ricardo da Conceição Marçal Alves Nunes Cristina Sofia de Jesus Monteiro Jorge Luiz dos Santos |
| author_facet | David Ricardo da Conceição Marçal Alves Nunes Cristina Sofia de Jesus Monteiro Jorge Luiz dos Santos |
| author_sort | David Ricardo da Conceição Marçal Alves Nunes |
| collection | DOAJ |
| description | Herb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality. |
| first_indexed | 2024-03-09T21:49:44Z |
| format | Article |
| id | doaj.art-5081d7943d004d8fb36a5e5fb3cc2692 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T21:49:44Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-5081d7943d004d8fb36a5e5fb3cc26922023-11-23T20:09:20ZengMDPI AGHealthcare2227-90322022-01-0110227810.3390/healthcare10020278Herb-Induced Liver Injury—A Challenging DiagnosisDavid Ricardo da Conceição Marçal Alves Nunes0Cristina Sofia de Jesus Monteiro1Jorge Luiz dos Santos2Faculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, PortugalFaculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, PortugalFaculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, PortugalHerb-induced liver injury (HILI) can be caused by supplements containing herbs, natural products, and products used in traditional medicine. Herbal products’ most common adverse reaction is hepatotoxicity. Almost every plant part can be used to make herbal products, and these products can come in many different forms, such as teas, powders, oils, creams, capsules, and injectables. HILI incidence and prevalence are hard to estimate and vary from study to study because of insufficient large-scale prospective studies. The diagnosis of HILI is a challenging process that requires not only insight but also a high degree of suspicion by the clinician. HILI presents with unspecific symptoms and is a diagnosis of exclusion. For diagnosis, it is necessary to make a causality assessment; the Council for International Organizations of Medical Sciences assessment is the preferred method worldwide. The most effective treatment is the suspension of the use of the suspected herbal product and close monitoring of liver function. The objective of this review is to highlight the necessary steps for the clinician to follow to reach a correct diagnosis of herb-induced liver injury. Further studies of HILI are needed to better understand its complexity and prevent increased morbidity and mortality.https://www.mdpi.com/2227-9032/10/2/278hepatotoxicityherbstraditional medicinecausality assessmentherbal quality |
| spellingShingle | David Ricardo da Conceição Marçal Alves Nunes Cristina Sofia de Jesus Monteiro Jorge Luiz dos Santos Herb-Induced Liver Injury—A Challenging Diagnosis Healthcare hepatotoxicity herbs traditional medicine causality assessment herbal quality |
| title | Herb-Induced Liver Injury—A Challenging Diagnosis |
| title_full | Herb-Induced Liver Injury—A Challenging Diagnosis |
| title_fullStr | Herb-Induced Liver Injury—A Challenging Diagnosis |
| title_full_unstemmed | Herb-Induced Liver Injury—A Challenging Diagnosis |
| title_short | Herb-Induced Liver Injury—A Challenging Diagnosis |
| title_sort | herb induced liver injury a challenging diagnosis |
| topic | hepatotoxicity herbs traditional medicine causality assessment herbal quality |
| url | https://www.mdpi.com/2227-9032/10/2/278 |
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