Nrf2 Modulation in Breast Cancer
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common patholog...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2668 |
| _version_ | 1797474920414838784 |
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| author | Somayyeh Ghareghomi Mehran Habibi-Rezaei Marzia Arese Luciano Saso Ali Akbar Moosavi-Movahedi |
| author_facet | Somayyeh Ghareghomi Mehran Habibi-Rezaei Marzia Arese Luciano Saso Ali Akbar Moosavi-Movahedi |
| author_sort | Somayyeh Ghareghomi |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common pathological processes, including various cancer types and neurodegenerative diseases, are inflammation and oxidative stress triggers, or even initiate them. Keap1-Nrf2 is a master antioxidant pathway in cytoprotective mechanisms through Nrf2 target gene expression. Activation of the Nfr2 pathway benefits cells in the early stages and reduces the level of ROS. In contrast, hyperactivation of Keap1-Nrf2 creates a context that supports the survival of both healthy and cancerous cells, defending them against oxidative stress, chemotherapeutic drugs, and radiotherapy. Considering the dual role of Nrf2 in suppressing or expanding cancer cells, determining its inhibitory/stimulatory position and targeting can represent an impressive role in cancer treatment. This review focused on Nrf2 modulators and their roles in sensitizing breast cancer cells to chemo/radiotherapy agents. |
| first_indexed | 2024-03-09T20:37:48Z |
| format | Article |
| id | doaj.art-5082c40d5d994c869c689e364a3593fd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:37:48Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5082c40d5d994c869c689e364a3593fd2023-11-23T23:06:51ZengMDPI AGBiomedicines2227-90592022-10-011010266810.3390/biomedicines10102668Nrf2 Modulation in Breast CancerSomayyeh Ghareghomi0Mehran Habibi-Rezaei1Marzia Arese2Luciano Saso3Ali Akbar Moosavi-Movahedi4Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, IranSchool of Biology, College of Science, University of Tehran, Tehran 1417466191, IranDepartment of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, IranReactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common pathological processes, including various cancer types and neurodegenerative diseases, are inflammation and oxidative stress triggers, or even initiate them. Keap1-Nrf2 is a master antioxidant pathway in cytoprotective mechanisms through Nrf2 target gene expression. Activation of the Nfr2 pathway benefits cells in the early stages and reduces the level of ROS. In contrast, hyperactivation of Keap1-Nrf2 creates a context that supports the survival of both healthy and cancerous cells, defending them against oxidative stress, chemotherapeutic drugs, and radiotherapy. Considering the dual role of Nrf2 in suppressing or expanding cancer cells, determining its inhibitory/stimulatory position and targeting can represent an impressive role in cancer treatment. This review focused on Nrf2 modulators and their roles in sensitizing breast cancer cells to chemo/radiotherapy agents.https://www.mdpi.com/2227-9059/10/10/2668oxidative stressantioxidant pathwayKeap1-Nrf2breast cancerNrf2 inhibitors |
| spellingShingle | Somayyeh Ghareghomi Mehran Habibi-Rezaei Marzia Arese Luciano Saso Ali Akbar Moosavi-Movahedi Nrf2 Modulation in Breast Cancer Biomedicines oxidative stress antioxidant pathway Keap1-Nrf2 breast cancer Nrf2 inhibitors |
| title | Nrf2 Modulation in Breast Cancer |
| title_full | Nrf2 Modulation in Breast Cancer |
| title_fullStr | Nrf2 Modulation in Breast Cancer |
| title_full_unstemmed | Nrf2 Modulation in Breast Cancer |
| title_short | Nrf2 Modulation in Breast Cancer |
| title_sort | nrf2 modulation in breast cancer |
| topic | oxidative stress antioxidant pathway Keap1-Nrf2 breast cancer Nrf2 inhibitors |
| url | https://www.mdpi.com/2227-9059/10/10/2668 |
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