A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years
Abstract Background The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors. Methods This retrospective single‐center cohort study enrolled 68 patients with newly d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4960 |
| _version_ | 1811176381059432448 |
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| author | Cheng‐Yu Tang Jen‐Fan Hang Yi‐Ping Hung Nai‐Chi Chiu Jiun‐I Lai Ming‐Huang Chen Chun‐Yu Liu Muh‐Hwa Yang Yee Chao Peter Mu‐Hsin Chang |
| author_facet | Cheng‐Yu Tang Jen‐Fan Hang Yi‐Ping Hung Nai‐Chi Chiu Jiun‐I Lai Ming‐Huang Chen Chun‐Yu Liu Muh‐Hwa Yang Yee Chao Peter Mu‐Hsin Chang |
| author_sort | Cheng‐Yu Tang |
| collection | DOAJ |
| description | Abstract Background The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors. Methods This retrospective single‐center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort. Results The median overall survival was 4.3 months in the study cohort (95% CI, 2.7–6.2 months) and 4.5 months in the historical cohort (95% CI, 3.0–5.5 months; p = 0.858). Eleven patients in the study cohort received immunotherapy. The disease control rates were 45%. Multivariate analysis showed that an Eastern Cooperative Oncology Group score > 1 and a C‐reactive protein level > 1 correlated with poor survival. A new prognostic stratification model was constructed by using Eastern Cooperative Oncology Group score and C‐reactive protein values. The good‐, intermediate‐, and poor‐risk groups had distinct median overall survival of 18.3, 7.0 and 1.2 months, respectively (area under the curve, 0.817; p < 0.001). Conclusion The outcome of unfavorable cancer of unknown primary has not changed much over the last 20 years. The application of a new prognostic stratification model can further stratify unfavorable cancer of unknown primary. |
| first_indexed | 2024-04-10T19:51:35Z |
| format | Article |
| id | doaj.art-5083ae094eaf4db9974114e04122f49f |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T19:51:35Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5083ae094eaf4db9974114e04122f49f2023-01-28T05:30:04ZengWileyCancer Medicine2045-76342023-01-011221090110110.1002/cam4.4960A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 yearsCheng‐Yu Tang0Jen‐Fan Hang1Yi‐Ping Hung2Nai‐Chi Chiu3Jiun‐I Lai4Ming‐Huang Chen5Chun‐Yu Liu6Muh‐Hwa Yang7Yee Chao8Peter Mu‐Hsin Chang9Division of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanSchool of Medicine National Yang Ming Chiao Tung University Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanSchool of Medicine National Yang Ming Chiao Tung University Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanDivision of Medical Oncology, Department of Oncology Taipei Veterans General Hospital Taipei TaiwanAbstract Background The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors. Methods This retrospective single‐center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort. Results The median overall survival was 4.3 months in the study cohort (95% CI, 2.7–6.2 months) and 4.5 months in the historical cohort (95% CI, 3.0–5.5 months; p = 0.858). Eleven patients in the study cohort received immunotherapy. The disease control rates were 45%. Multivariate analysis showed that an Eastern Cooperative Oncology Group score > 1 and a C‐reactive protein level > 1 correlated with poor survival. A new prognostic stratification model was constructed by using Eastern Cooperative Oncology Group score and C‐reactive protein values. The good‐, intermediate‐, and poor‐risk groups had distinct median overall survival of 18.3, 7.0 and 1.2 months, respectively (area under the curve, 0.817; p < 0.001). Conclusion The outcome of unfavorable cancer of unknown primary has not changed much over the last 20 years. The application of a new prognostic stratification model can further stratify unfavorable cancer of unknown primary.https://doi.org/10.1002/cam4.4960C‐reactive proteinperformance statusprognosisunknown primary tumors |
| spellingShingle | Cheng‐Yu Tang Jen‐Fan Hang Yi‐Ping Hung Nai‐Chi Chiu Jiun‐I Lai Ming‐Huang Chen Chun‐Yu Liu Muh‐Hwa Yang Yee Chao Peter Mu‐Hsin Chang A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years Cancer Medicine C‐reactive protein performance status prognosis unknown primary tumors |
| title | A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| title_full | A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| title_fullStr | A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| title_full_unstemmed | A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| title_short | A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| title_sort | generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years |
| topic | C‐reactive protein performance status prognosis unknown primary tumors |
| url | https://doi.org/10.1002/cam4.4960 |
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