Two distinct phenotypes of immunologically hot gastric cancer subtypes
An in-depth understanding of the tumor microenvironment (TME) is required for the development of improved combination immunotherapies for gastric cancer. Recently, we classified these cancers into four main types defined by their immunological attributes, namely Hot 1, Hot 2, Intermediate and Cold....
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580821002612 |
| _version_ | 1818353093410029568 |
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| author | Noriyuki Saito Yukari Kobayashi Koji Nagaoka Yoshihiro Kushihara Yasuyoshi Sato Ikuo Wada Kazuhiro Kakimi Yasuyuki Seto |
| author_facet | Noriyuki Saito Yukari Kobayashi Koji Nagaoka Yoshihiro Kushihara Yasuyoshi Sato Ikuo Wada Kazuhiro Kakimi Yasuyuki Seto |
| author_sort | Noriyuki Saito |
| collection | DOAJ |
| description | An in-depth understanding of the tumor microenvironment (TME) is required for the development of improved combination immunotherapies for gastric cancer. Recently, we classified these cancers into four main types defined by their immunological attributes, namely Hot 1, Hot 2, Intermediate and Cold. Of these, the T cell-inflamed “Hot” tumors were further divided into Hot 1 and Hot 2 with different clinical outcomes. Thus, overall survival and progression-free survival of patients with Hot 1 tumors were shorter than with Hot 2. In the present study, we re-evaluated RNA-Seq data of 6 Hot 1 and 6 Hot 2 gastric cancers to elucidate the underlying reason for the poor prognosis and T cell dysfunction in the former. In addition, 56 Hot 1 and 27 Hot 2 tumors in The Cancer Genome Atlas (TCGA) were analyzed. We report that single sample Gene Set Enrichment Analysis (ssGSEA) and differential gene expression analysis identified differences between Hot 1 and Hot 2 tumors involved in metabolism and cell adhesion pathways. Therefore, it is suggested that strategies to modulate active metabolism in Hot 1 tumors should be integrated into the treatment of these gastric cancers. |
| first_indexed | 2024-12-13T19:04:03Z |
| format | Article |
| id | doaj.art-5083fbf3126d4e1a8af51c48ba6dc19f |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-13T19:04:03Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-5083fbf3126d4e1a8af51c48ba6dc19f2022-12-21T23:34:37ZengElsevierBiochemistry and Biophysics Reports2405-58082021-12-0128101167Two distinct phenotypes of immunologically hot gastric cancer subtypesNoriyuki Saito0Yukari Kobayashi1Koji Nagaoka2Yoshihiro Kushihara3Yasuyoshi Sato4Ikuo Wada5Kazuhiro Kakimi6Yasuyuki Seto7Department of Gastrointestinal Surgery, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanDepartment of Immunotherapeutics, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Immunotherapeutics, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Immunotherapeutics, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanDepartment of Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanDepartment of Immunotherapeutics, The University of Tokyo Hospital, Tokyo 113-8655, Japan; Corresponding author. The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.Department of Gastrointestinal Surgery, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanAn in-depth understanding of the tumor microenvironment (TME) is required for the development of improved combination immunotherapies for gastric cancer. Recently, we classified these cancers into four main types defined by their immunological attributes, namely Hot 1, Hot 2, Intermediate and Cold. Of these, the T cell-inflamed “Hot” tumors were further divided into Hot 1 and Hot 2 with different clinical outcomes. Thus, overall survival and progression-free survival of patients with Hot 1 tumors were shorter than with Hot 2. In the present study, we re-evaluated RNA-Seq data of 6 Hot 1 and 6 Hot 2 gastric cancers to elucidate the underlying reason for the poor prognosis and T cell dysfunction in the former. In addition, 56 Hot 1 and 27 Hot 2 tumors in The Cancer Genome Atlas (TCGA) were analyzed. We report that single sample Gene Set Enrichment Analysis (ssGSEA) and differential gene expression analysis identified differences between Hot 1 and Hot 2 tumors involved in metabolism and cell adhesion pathways. Therefore, it is suggested that strategies to modulate active metabolism in Hot 1 tumors should be integrated into the treatment of these gastric cancers.http://www.sciencedirect.com/science/article/pii/S2405580821002612Gastric cancerTumor immunityRNA-SeqT cell-inflamedHot tumor |
| spellingShingle | Noriyuki Saito Yukari Kobayashi Koji Nagaoka Yoshihiro Kushihara Yasuyoshi Sato Ikuo Wada Kazuhiro Kakimi Yasuyuki Seto Two distinct phenotypes of immunologically hot gastric cancer subtypes Biochemistry and Biophysics Reports Gastric cancer Tumor immunity RNA-Seq T cell-inflamed Hot tumor |
| title | Two distinct phenotypes of immunologically hot gastric cancer subtypes |
| title_full | Two distinct phenotypes of immunologically hot gastric cancer subtypes |
| title_fullStr | Two distinct phenotypes of immunologically hot gastric cancer subtypes |
| title_full_unstemmed | Two distinct phenotypes of immunologically hot gastric cancer subtypes |
| title_short | Two distinct phenotypes of immunologically hot gastric cancer subtypes |
| title_sort | two distinct phenotypes of immunologically hot gastric cancer subtypes |
| topic | Gastric cancer Tumor immunity RNA-Seq T cell-inflamed Hot tumor |
| url | http://www.sciencedirect.com/science/article/pii/S2405580821002612 |
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