Phage Endolysins: Advances in the World of Food Safety
As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell walls. They have emerged as promising antibacte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/17/2169 |
| _version_ | 1797582727955873792 |
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| author | Amina Nazir Xiaohui Xu Yuqing Liu Yibao Chen |
| author_facet | Amina Nazir Xiaohui Xu Yuqing Liu Yibao Chen |
| author_sort | Amina Nazir |
| collection | DOAJ |
| description | As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell walls. They have emerged as promising antibacterial agents suitable for integration into food processing systems. Their application as food preservatives can effectively regulate pathogens, thus contributing to an overall improvement in food safety. This review summarizes the latest techniques considering endolysins’ potential for food safety. These techniques include native and engineered endolysins for controlling bacterial contamination at different points within the food production chain. However, we find that characterizing endolysins through in vitro methods proves to be time consuming and resource intensive. Alternatively, the emergence of advanced high-throughput sequencing technology necessitates the creation of a robust computational framework to efficiently characterize recently identified endolysins, paving the way for future research. Machine learning encompasses potent tools capable of analyzing intricate datasets and pattern recognition. This study briefly reviewed the use of these industry 4.0 technologies for advancing the research in food industry. We aimed to provide current status of endolysins in food industry and new insights by implementing these industry 4.0 strategies revolutionizes endolysin development. It will enhance food safety, customization, efficiency, transparency, and collaboration while reducing regulatory hurdles and ensuring timely product availability. |
| first_indexed | 2024-03-10T23:25:38Z |
| format | Article |
| id | doaj.art-5085125395c448e3ae24209c9a343a8b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T23:25:38Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5085125395c448e3ae24209c9a343a8b2023-11-19T07:58:12ZengMDPI AGCells2073-44092023-08-011217216910.3390/cells12172169Phage Endolysins: Advances in the World of Food SafetyAmina Nazir0Xiaohui Xu1Yuqing Liu2Yibao Chen3Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, ChinaShandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, ChinaShandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, ChinaShandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, ChinaAs antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell walls. They have emerged as promising antibacterial agents suitable for integration into food processing systems. Their application as food preservatives can effectively regulate pathogens, thus contributing to an overall improvement in food safety. This review summarizes the latest techniques considering endolysins’ potential for food safety. These techniques include native and engineered endolysins for controlling bacterial contamination at different points within the food production chain. However, we find that characterizing endolysins through in vitro methods proves to be time consuming and resource intensive. Alternatively, the emergence of advanced high-throughput sequencing technology necessitates the creation of a robust computational framework to efficiently characterize recently identified endolysins, paving the way for future research. Machine learning encompasses potent tools capable of analyzing intricate datasets and pattern recognition. This study briefly reviewed the use of these industry 4.0 technologies for advancing the research in food industry. We aimed to provide current status of endolysins in food industry and new insights by implementing these industry 4.0 strategies revolutionizes endolysin development. It will enhance food safety, customization, efficiency, transparency, and collaboration while reducing regulatory hurdles and ensuring timely product availability.https://www.mdpi.com/2073-4409/12/17/2169food preservativesantibacterialbiocontrolapplicationsfood pathogens |
| spellingShingle | Amina Nazir Xiaohui Xu Yuqing Liu Yibao Chen Phage Endolysins: Advances in the World of Food Safety Cells food preservatives antibacterial biocontrol applications food pathogens |
| title | Phage Endolysins: Advances in the World of Food Safety |
| title_full | Phage Endolysins: Advances in the World of Food Safety |
| title_fullStr | Phage Endolysins: Advances in the World of Food Safety |
| title_full_unstemmed | Phage Endolysins: Advances in the World of Food Safety |
| title_short | Phage Endolysins: Advances in the World of Food Safety |
| title_sort | phage endolysins advances in the world of food safety |
| topic | food preservatives antibacterial biocontrol applications food pathogens |
| url | https://www.mdpi.com/2073-4409/12/17/2169 |
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