Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy).

Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy).

Selection of lung cancer patients for therapy with tyrosine kinase inhibitors directed at EGFR requires the identification of specific EGFR mutations. In most patients with advanced, inoperable lung carcinoma limited tumor samples often represent the only material available for both histologic typin...

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Bibliographic Details
Main Authors: Dario de Biase, Michela Visani, Umberto Malapelle, Francesca Simonato, Valentina Cesari, Claudio Bellevicine, Annalisa Pession, Giancarlo Troncone, Ambrogio Fassina, Giovanni Tallini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871524?pdf=render

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