Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/13/1/96/ |
| _version_ | 1828531099862564864 |
|---|---|
| author | Waclaw Kolodziejski Ewa Olędzka Ewa Witkowska Marcin Sobczak |
| author_facet | Waclaw Kolodziejski Ewa Olędzka Ewa Witkowska Marcin Sobczak |
| author_sort | Waclaw Kolodziejski |
| collection | DOAJ |
| description | Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies. |
| first_indexed | 2024-12-11T22:32:53Z |
| format | Article |
| id | doaj.art-50858109e9004fd5ab647f2d2407a707 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T22:32:53Z |
| publishDate | 2008-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-50858109e9004fd5ab647f2d2407a7072022-12-22T00:48:04ZengMDPI AGMolecules1420-30492008-01-011319610610.3390/molecules13010096Synthesis and Structural Analysis of Polyester Prodrugs of NorfloxacinWaclaw KolodziejskiEwa OlędzkaEwa WitkowskaMarcin SobczakTwo-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies.http://www.mdpi.com/1420-3049/13/1/96/aliphatic polyestersring-opening polymerizationmacromolecular prodrugs |
| spellingShingle | Waclaw Kolodziejski Ewa Olędzka Ewa Witkowska Marcin Sobczak Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin Molecules aliphatic polyesters ring-opening polymerization macromolecular prodrugs |
| title | Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin |
| title_full | Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin |
| title_fullStr | Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin |
| title_full_unstemmed | Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin |
| title_short | Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin |
| title_sort | synthesis and structural analysis of polyester prodrugs of norfloxacin |
| topic | aliphatic polyesters ring-opening polymerization macromolecular prodrugs |
| url | http://www.mdpi.com/1420-3049/13/1/96/ |
| work_keys_str_mv | AT waclawkolodziejski synthesisandstructuralanalysisofpolyesterprodrugsofnorfloxacin AT ewaolaadzka synthesisandstructuralanalysisofpolyesterprodrugsofnorfloxacin AT ewawitkowska synthesisandstructuralanalysisofpolyesterprodrugsofnorfloxacin AT marcinsobczak synthesisandstructuralanalysisofpolyesterprodrugsofnorfloxacin |