Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression
BEND3 is a transcription factor that plays a critical role in the regulation of gene expression in mammals. While there is limited research on the role of BEND3 as a tumor suppressor or an oncogene and its potential role in cancer therapy is still emerging, several studies suggest that it may be inv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/14/3685 |
| _version_ | 1797589888979173376 |
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| author | Sarah Naiyer Lalita Dwivedi Nishant Singh Swastik Phulera Vijay Mohan Mohammad Kamran |
| author_facet | Sarah Naiyer Lalita Dwivedi Nishant Singh Swastik Phulera Vijay Mohan Mohammad Kamran |
| author_sort | Sarah Naiyer |
| collection | DOAJ |
| description | BEND3 is a transcription factor that plays a critical role in the regulation of gene expression in mammals. While there is limited research on the role of BEND3 as a tumor suppressor or an oncogene and its potential role in cancer therapy is still emerging, several studies suggest that it may be involved in both the processes. Its interaction and regulation with multiple other factors via p21 have already been reported to play a significant role in cancer development, which serves as an indication of its potential role in oncogenesis. Its interaction with chromatin modifiers such as NuRD and NoRC and its role in the recruitment of polycomb repressive complex 2 (PRC2) are some of the additional events indicative of its potential role in cancer development. Moreover, a few recent studies indicate BEND3 as a potential target for cancer therapy. Since the specific mechanisms by which BEND3 may contribute to cancer progression are not yet fully elucidated, in this review, we have discussed the possible pathways BEND3 may take to serve as an oncogenic driver or suppressor. |
| first_indexed | 2024-03-11T01:12:32Z |
| format | Article |
| id | doaj.art-508637e64a56488fa4284b7bf8cac186 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:12:32Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-508637e64a56488fa4284b7bf8cac1862023-11-18T18:42:40ZengMDPI AGCancers2072-66942023-07-011514368510.3390/cancers15143685Role of Transcription Factor BEND3 and Its Potential Effect on Cancer ProgressionSarah Naiyer0Lalita Dwivedi1Nishant Singh2Swastik Phulera3Vijay Mohan4Mohammad Kamran5Department of Biomedical Science, University of Pennsylvania, Philadelphia, PA 19104, USAFaculty of Science, Department of Biotechnology, Invertis University, Bareilly 243122, UP, IndiaCell and Gene Therapy Division Absorption System, Exton, PA 19341, USAInitium Therapeutics, 22 Strathmore Rd., STE 453, Natick, MA 01760, USADepartment of Biosciences, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, UP, IndiaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USABEND3 is a transcription factor that plays a critical role in the regulation of gene expression in mammals. While there is limited research on the role of BEND3 as a tumor suppressor or an oncogene and its potential role in cancer therapy is still emerging, several studies suggest that it may be involved in both the processes. Its interaction and regulation with multiple other factors via p21 have already been reported to play a significant role in cancer development, which serves as an indication of its potential role in oncogenesis. Its interaction with chromatin modifiers such as NuRD and NoRC and its role in the recruitment of polycomb repressive complex 2 (PRC2) are some of the additional events indicative of its potential role in cancer development. Moreover, a few recent studies indicate BEND3 as a potential target for cancer therapy. Since the specific mechanisms by which BEND3 may contribute to cancer progression are not yet fully elucidated, in this review, we have discussed the possible pathways BEND3 may take to serve as an oncogenic driver or suppressor.https://www.mdpi.com/2072-6694/15/14/3685BEND3tumor suppressoroncogenic drivercancer therapy |
| spellingShingle | Sarah Naiyer Lalita Dwivedi Nishant Singh Swastik Phulera Vijay Mohan Mohammad Kamran Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression Cancers BEND3 tumor suppressor oncogenic driver cancer therapy |
| title | Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression |
| title_full | Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression |
| title_fullStr | Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression |
| title_full_unstemmed | Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression |
| title_short | Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression |
| title_sort | role of transcription factor bend3 and its potential effect on cancer progression |
| topic | BEND3 tumor suppressor oncogenic driver cancer therapy |
| url | https://www.mdpi.com/2072-6694/15/14/3685 |
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