Adenylate kinase 1 overexpression increases locomotor activity in medaka fish
Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms. Ak plays an essential role in energy regulation by maintaining adenine nucleotide homeostasis in cells. However, its role at the whol...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726475/?tool=EBI |
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author | Michiyo Maruyama Yuko Furukawa Masato Kinoshita Atsushi Mukaiyama Shuji Akiyama Takashi Yoshimura |
author_facet | Michiyo Maruyama Yuko Furukawa Masato Kinoshita Atsushi Mukaiyama Shuji Akiyama Takashi Yoshimura |
author_sort | Michiyo Maruyama |
collection | DOAJ |
description | Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms. Ak plays an essential role in energy regulation by maintaining adenine nucleotide homeostasis in cells. However, its role at the whole organism level, especially in animal behavior, remains unclear. Here, we established a model using medaka fish (Oryzias latipes) to examine the function of Ak in environmental adaptation. Medaka overexpressing the major Ak isoform Ak1 exhibited increased locomotor activity compared to that of the wild type. Interestingly, this increase was temperature dependent. Our findings suggest that cellular energy balance can modulate locomotor activity. |
first_indexed | 2024-04-11T21:00:07Z |
format | Article |
id | doaj.art-50867e3b833f4da8bf0e558889e75eea |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-04-11T21:00:07Z |
publishDate | 2022-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-50867e3b833f4da8bf0e558889e75eea2022-12-22T04:03:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171Adenylate kinase 1 overexpression increases locomotor activity in medaka fishMichiyo MaruyamaYuko FurukawaMasato KinoshitaAtsushi MukaiyamaShuji AkiyamaTakashi YoshimuraMaintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms. Ak plays an essential role in energy regulation by maintaining adenine nucleotide homeostasis in cells. However, its role at the whole organism level, especially in animal behavior, remains unclear. Here, we established a model using medaka fish (Oryzias latipes) to examine the function of Ak in environmental adaptation. Medaka overexpressing the major Ak isoform Ak1 exhibited increased locomotor activity compared to that of the wild type. Interestingly, this increase was temperature dependent. Our findings suggest that cellular energy balance can modulate locomotor activity.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726475/?tool=EBI |
spellingShingle | Michiyo Maruyama Yuko Furukawa Masato Kinoshita Atsushi Mukaiyama Shuji Akiyama Takashi Yoshimura Adenylate kinase 1 overexpression increases locomotor activity in medaka fish PLoS ONE |
title | Adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
title_full | Adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
title_fullStr | Adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
title_full_unstemmed | Adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
title_short | Adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
title_sort | adenylate kinase 1 overexpression increases locomotor activity in medaka fish |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726475/?tool=EBI |
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