Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro
3CLpro of SARS-CoV-2 is a promising target for developing anti-COVID19 agents. In order to evaluate the catalytic activity of 3CLpros according to the presence or absence of the dimerization domain, two forms had been purified and tested. Enzyme kinetic studies with a FRET method revealed that the c...
Main Authors: | Seri Jo, Hwa Young Kim, Dong Hae Shin, Mi-Sun Kim |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/9/5268 |
Similar Items
-
A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2
by: Seri Jo, et al.
Published: (2021-04-01) -
A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) Inhibitors
by: Seri Jo, et al.
Published: (2022-06-01) -
The main protease 3CLpro of the SARS-CoV-2 virus: how to turn an enemy into a helper
by: Svetlana V. Belenkaya, et al.
Published: (2023-06-01) -
Corrigendum: The main protease 3CLpro of the SARS-CoV-2 virus: how to turn an enemy into a helper
by: Svetlana V. Belenkaya, et al.
Published: (2023-11-01) -
Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain
by: Yunseok Heo, et al.
Published: (2022-04-01)