Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects
Drugs that inhibit bone resorption are prescribed most often by orthopedists, hematologists, or oncologists. Dental practice rarely draws attention to their importance and the effects they carry. The problem concerns mainly older people owing to oncological problems or postmenopausal consequences, b...
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MDPI AG
2021-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/3/354 |
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| author | Filip Michalak Sylwia Hnitecka Marzena Dominiak Kinga Grzech-Leśniak |
| author_facet | Filip Michalak Sylwia Hnitecka Marzena Dominiak Kinga Grzech-Leśniak |
| author_sort | Filip Michalak |
| collection | DOAJ |
| description | Drugs that inhibit bone resorption are prescribed most often by orthopedists, hematologists, or oncologists. Dental practice rarely draws attention to their importance and the effects they carry. The problem concerns mainly older people owing to oncological problems or postmenopausal consequences, but everyone can be at risk. Carefully conducted interviews and analysis of history and disease should always be performed before any action is taken by patients taking this type of medicine. Further action should consider possible complications and, above all, the risk of their occurrence. In this article, the most important issues related to the treatment of drug-induced osteonecrosis of the jaws (ONJ) are raised, including medication-related osteonecrosis of the jaw (MRONJ); conservative treatment, including the use of laser; and the impact of vitamin D supplementation on the overall treatment, prognosis, and prevention before complication, which is osteonecrosis of the jaw in the course of treatment with bisphosphonates and other drugs predisposing to MRONJ, such as denosumab and angiogenesis inhibitors. The degree of osteonecrosis is also critical, as it is possible to avoid surgical procedures for only conservative methods that sometimes bring good results. Surgical treatment of advanced stages is complicated and carries a high risk of error and complications. MRONJ is a disease that is easy to avoid, but it is difficult to treat and treatment sometimes leads only to a partial remission of the disease, not a complete cure. |
| first_indexed | 2024-03-09T05:01:57Z |
| format | Article |
| id | doaj.art-50894553c143436baa014f3d4bdaff5f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T05:01:57Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-50894553c143436baa014f3d4bdaff5f2023-12-03T12:59:00ZengMDPI AGPharmaceutics1999-49232021-03-0113335410.3390/pharmaceutics13030354Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic EffectsFilip Michalak0Sylwia Hnitecka1Marzena Dominiak2Kinga Grzech-Leśniak3Oral Surgery Department, Wroclaw Medical University, 50-367 Wroclaw, PolandMaxillofacial Surgery Department, Wroclaw Medical University, 50-556 Wroclaw, PolandOral Surgery Department, Wroclaw Medical University, 50-367 Wroclaw, PolandOral Surgery Department, Wroclaw Medical University, 50-367 Wroclaw, PolandDrugs that inhibit bone resorption are prescribed most often by orthopedists, hematologists, or oncologists. Dental practice rarely draws attention to their importance and the effects they carry. The problem concerns mainly older people owing to oncological problems or postmenopausal consequences, but everyone can be at risk. Carefully conducted interviews and analysis of history and disease should always be performed before any action is taken by patients taking this type of medicine. Further action should consider possible complications and, above all, the risk of their occurrence. In this article, the most important issues related to the treatment of drug-induced osteonecrosis of the jaws (ONJ) are raised, including medication-related osteonecrosis of the jaw (MRONJ); conservative treatment, including the use of laser; and the impact of vitamin D supplementation on the overall treatment, prognosis, and prevention before complication, which is osteonecrosis of the jaw in the course of treatment with bisphosphonates and other drugs predisposing to MRONJ, such as denosumab and angiogenesis inhibitors. The degree of osteonecrosis is also critical, as it is possible to avoid surgical procedures for only conservative methods that sometimes bring good results. Surgical treatment of advanced stages is complicated and carries a high risk of error and complications. MRONJ is a disease that is easy to avoid, but it is difficult to treat and treatment sometimes leads only to a partial remission of the disease, not a complete cure.https://www.mdpi.com/1999-4923/13/3/354bisphosphonatesMRONJlaser therapyvitamin Dosteonecrosis |
| spellingShingle | Filip Michalak Sylwia Hnitecka Marzena Dominiak Kinga Grzech-Leśniak Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects Pharmaceutics bisphosphonates MRONJ laser therapy vitamin D osteonecrosis |
| title | Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects |
| title_full | Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects |
| title_fullStr | Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects |
| title_full_unstemmed | Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects |
| title_short | Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects |
| title_sort | schemes for drug induced treatment of osteonecrosis of jaws with particular emphasis on the influence of vitamin d on therapeutic effects |
| topic | bisphosphonates MRONJ laser therapy vitamin D osteonecrosis |
| url | https://www.mdpi.com/1999-4923/13/3/354 |
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