Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries.

Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries.

<h4>Background</h4>The amplification of GTP cyclohydrolase 1 (pfgch1) in Plasmodium falciparum has been linked to the upregulation of the pfdhfr and pfdhps genes associated with resistance to the antimalarial drug sulfadoxine-pyrimethamine. During the 1990s and 2000s, sulfadoxine-pyrimet...

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Main Authors: Suttipat Srisutham, Wanassanan Madmanee, Jindarat Kouhathong, Kreepol Sutawong, Rupam Tripura, Thomas J Peto, Rob W van der Pluijm, James J Callery, Lek Dysoley, Mayfong Mayxay, Paul N Newton, Tiengkham Pongvongsa, Bouasy Hongvanthong, Nicholas P J Day, Nicholas J White, Arjen M Dondorp, Mallika Imwong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0278928

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