An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer
Abstract Ovarian cancer is one of the most common female reproductive system malignancies worldwide. Recently, the aberrant long noncoding RNAs (lncRNAs) expression has been identified in multiple cancers. Emerging evidence has highlighted the critical roles of lncRNAs in carcinogenesis and tumor pr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2171 |
| _version_ | 1811335059262668800 |
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| author | Jing Wang Yongju Tian Hui Zheng Yan Ding Xiuli Wang |
| author_facet | Jing Wang Yongju Tian Hui Zheng Yan Ding Xiuli Wang |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Abstract Ovarian cancer is one of the most common female reproductive system malignancies worldwide. Recently, the aberrant long noncoding RNAs (lncRNAs) expression has been identified in multiple cancers. Emerging evidence has highlighted the critical roles of lncRNAs in carcinogenesis and tumor progression, including ovarian cancer. The objective of this study is to comprehensively analyze lncRNAs expression pattern, and explore their clinical significance and underlying mechanism in human ovarian cancer. In this study, we found hundreds of dysregulated lncRNAs in ovarian cancer by performing genome‐wide analysis using RNA sequencing data from Genotype‐Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) project, and three microarray datasets from Gene Expression Omnibus (GEO). Moreover, our results revealed that up‐ or down‐regulation of some lncRNAs expression in ovarian cancer is accompanied by their genomic loci copy number amplification or deletion. Importantly, some lncRNAs expression levels are significantly associated with ovarian cancer patients’ poor prognosis. Further experimental validation and mechanistic investigation indicate that LINC00511 exerts oncogenic function in ovarian cancer cells through interacting with EZH2 and repressing P21 expression. Taken together, the findings in the current study may provide a useful resource of novel ovarian cancer associated lncRNAs and potential diagnostic biomarker and therapeutic targets for ovarian cancer. |
| first_indexed | 2024-04-13T17:18:24Z |
| format | Article |
| id | doaj.art-508ad5addbb548f08ebaa826fcab8e6d |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-13T17:18:24Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-508ad5addbb548f08ebaa826fcab8e6d2022-12-22T02:38:04ZengWileyCancer Medicine2045-76342019-06-01863026303510.1002/cam4.2171An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancerJing Wang0Yongju Tian1Hui Zheng2Yan Ding3Xiuli Wang4Department of Obstetrics and Gynecology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai, Shandong P.R ChinaDepartment of Gynecology Yantaishan Hospital Yantai, Shandong P.R ChinaDepartment of Gastrointestinal Surgery The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai, Shandong P.R ChinaDepartment of Spine Yantaishan Hospital Yantai, Shandong P.R ChinaDepartment of Obstetrics and Gynecology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai, Shandong P.R ChinaAbstract Ovarian cancer is one of the most common female reproductive system malignancies worldwide. Recently, the aberrant long noncoding RNAs (lncRNAs) expression has been identified in multiple cancers. Emerging evidence has highlighted the critical roles of lncRNAs in carcinogenesis and tumor progression, including ovarian cancer. The objective of this study is to comprehensively analyze lncRNAs expression pattern, and explore their clinical significance and underlying mechanism in human ovarian cancer. In this study, we found hundreds of dysregulated lncRNAs in ovarian cancer by performing genome‐wide analysis using RNA sequencing data from Genotype‐Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) project, and three microarray datasets from Gene Expression Omnibus (GEO). Moreover, our results revealed that up‐ or down‐regulation of some lncRNAs expression in ovarian cancer is accompanied by their genomic loci copy number amplification or deletion. Importantly, some lncRNAs expression levels are significantly associated with ovarian cancer patients’ poor prognosis. Further experimental validation and mechanistic investigation indicate that LINC00511 exerts oncogenic function in ovarian cancer cells through interacting with EZH2 and repressing P21 expression. Taken together, the findings in the current study may provide a useful resource of novel ovarian cancer associated lncRNAs and potential diagnostic biomarker and therapeutic targets for ovarian cancer.https://doi.org/10.1002/cam4.2171EZH2LINC00511long noncoding RNAovarian cancerP21 |
| spellingShingle | Jing Wang Yongju Tian Hui Zheng Yan Ding Xiuli Wang An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer Cancer Medicine EZH2 LINC00511 long noncoding RNA ovarian cancer P21 |
| title | An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer |
| title_full | An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer |
| title_fullStr | An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer |
| title_full_unstemmed | An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer |
| title_short | An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer |
| title_sort | integrated analysis reveals the oncogenic function of lncrna linc00511 in human ovarian cancer |
| topic | EZH2 LINC00511 long noncoding RNA ovarian cancer P21 |
| url | https://doi.org/10.1002/cam4.2171 |
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