The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease

The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease

Abstract Background Pulmonary hypertension (PH) is a complex multifactorial vascular pathology characterized by an increased pulmonary arterial pressure, vasoconstriction, remodelling of the pulmonary vasculature, thrombosis in situ and inflammation associated with right-side heart failure. Herein,...

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Bibliographic Details
Main Authors: Ioana Karla Comarița, Gabriela Tanko, Iliuță Laurențiu Anghelache, Adriana Georgescu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Cardiopulmonary disease
Pulmonary arterial hypertension
Cardiac and pulmonary fibrosis
Monocrotaline
siRNA AP-1
Online Access:https://doi.org/10.1186/s12967-024-04933-1

Internet

https://doi.org/10.1186/s12967-024-04933-1

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