Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer
In men, prostate cancer is the most frequently diagnosed malignancy worldwide. Early diagnosis improves its prognosis, with higher survival rates and a better quality of life for patients. However, diagnosis and characterization of tumors are mainly based on highly invasive tissue biopsies, with an...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biosensors and Bioelectronics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590137022001200 |
| _version_ | 1811184525259046912 |
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| author | Raquel Sánchez-Salcedo Paula Gómez-Meijide Rebeca Miranda-Castro Noemí de-los-Santos-Álvarez María Jesús Lobo-Castañón |
| author_facet | Raquel Sánchez-Salcedo Paula Gómez-Meijide Rebeca Miranda-Castro Noemí de-los-Santos-Álvarez María Jesús Lobo-Castañón |
| author_sort | Raquel Sánchez-Salcedo |
| collection | DOAJ |
| description | In men, prostate cancer is the most frequently diagnosed malignancy worldwide. Early diagnosis improves its prognosis, with higher survival rates and a better quality of life for patients. However, diagnosis and characterization of tumors are mainly based on highly invasive tissue biopsies, with an incomplete representation of the entire tumor. In consequence, attention is turning to the so-called liquid biopsies, which provide molecular information about the tumor by detecting its specific components, including proteins, circulating nucleic acids or tumor cells, in bodily fluids such as blood or urine. Recent years have seen the development of a large number of electrochemical sensors employing oligonucleotides for the recognition of prostate tumor components in a minimal invasive way. Here we survey the reported designs, which are categorized as aptasensors and genosensors for the different molecular components identified as prostate cancer biomarkers. We present a critical evaluation of their analytical validity, identifying the challenges of bringing these devices to the clinical practice. |
| first_indexed | 2024-04-11T13:14:38Z |
| format | Article |
| id | doaj.art-508b8aba84d946ea8f69174d69f8f67f |
| institution | Directory Open Access Journal |
| issn | 2590-1370 |
| language | English |
| last_indexed | 2024-04-11T13:14:38Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosensors and Bioelectronics: X |
| spelling | doaj.art-508b8aba84d946ea8f69174d69f8f67f2022-12-22T04:22:27ZengElsevierBiosensors and Bioelectronics: X2590-13702022-12-0112100227Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancerRaquel Sánchez-Salcedo0Paula Gómez-Meijide1Rebeca Miranda-Castro2Noemí de-los-Santos-Álvarez3María Jesús Lobo-Castañón4Departamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, SpainDepartamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, SpainDepartamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, SpainDepartamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, SpainDepartamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, Spain; Corresponding author. Departamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain.In men, prostate cancer is the most frequently diagnosed malignancy worldwide. Early diagnosis improves its prognosis, with higher survival rates and a better quality of life for patients. However, diagnosis and characterization of tumors are mainly based on highly invasive tissue biopsies, with an incomplete representation of the entire tumor. In consequence, attention is turning to the so-called liquid biopsies, which provide molecular information about the tumor by detecting its specific components, including proteins, circulating nucleic acids or tumor cells, in bodily fluids such as blood or urine. Recent years have seen the development of a large number of electrochemical sensors employing oligonucleotides for the recognition of prostate tumor components in a minimal invasive way. Here we survey the reported designs, which are categorized as aptasensors and genosensors for the different molecular components identified as prostate cancer biomarkers. We present a critical evaluation of their analytical validity, identifying the challenges of bringing these devices to the clinical practice.http://www.sciencedirect.com/science/article/pii/S2590137022001200GenosensorsAptamersProstate cancerPSALiquid biopsy |
| spellingShingle | Raquel Sánchez-Salcedo Paula Gómez-Meijide Rebeca Miranda-Castro Noemí de-los-Santos-Álvarez María Jesús Lobo-Castañón Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer Biosensors and Bioelectronics: X Genosensors Aptamers Prostate cancer PSA Liquid biopsy |
| title | Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| title_full | Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| title_fullStr | Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| title_full_unstemmed | Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| title_short | Electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| title_sort | electrochemical sensors using oligonucleotides as recognition ligands for liquid biopsy in prostate cancer |
| topic | Genosensors Aptamers Prostate cancer PSA Liquid biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S2590137022001200 |
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