Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/1/60 |
| _version_ | 1797440395857100800 |
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| author | P. Veeraraghavan Ramachandran Abdulkhaliq A. Alawaed |
| author_facet | P. Veeraraghavan Ramachandran Abdulkhaliq A. Alawaed |
| author_sort | P. Veeraraghavan Ramachandran |
| collection | DOAJ |
| description | The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup. |
| first_indexed | 2024-03-09T12:07:33Z |
| format | Article |
| id | doaj.art-508b95032580453db389fcc3c70e666c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:07:33Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-508b95032580453db389fcc3c70e666c2023-11-30T22:56:19ZengMDPI AGMolecules1420-30492022-12-012816010.3390/molecules28010060Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-BoraneP. Veeraraghavan Ramachandran0Abdulkhaliq A. Alawaed1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USADepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USAThe reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup.https://www.mdpi.com/1420-3049/28/1/60reductionammonia-boranenitrileprimary aminestitanium tetrachloridecatalysis |
| spellingShingle | P. Veeraraghavan Ramachandran Abdulkhaliq A. Alawaed Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane Molecules reduction ammonia-borane nitrile primary amines titanium tetrachloride catalysis |
| title | Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane |
| title_full | Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane |
| title_fullStr | Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane |
| title_full_unstemmed | Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane |
| title_short | Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane |
| title_sort | room temperature reduction of titanium tetrachloride activated nitriles to primary amines with ammonia borane |
| topic | reduction ammonia-borane nitrile primary amines titanium tetrachloride catalysis |
| url | https://www.mdpi.com/1420-3049/28/1/60 |
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