Assessment of tissue level of interleukin-9 in psoriasis and vitiligo
Background Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disease that occurs due to the loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine that was initially designated as a T helper2 cyt...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
| Subjects: | |
| Online Access: | http://www.jewd.eg.net//article.asp?issn=1687-1537;year=2023;volume=20;issue=3;spage=162;epage=167;aulast=Mahmoud |
| _version_ | 1797645629799792640 |
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| author | Sara B Mahmoud Nesma A.M Salem Olfat G Shaker Aya M Fahim |
| author_facet | Sara B Mahmoud Nesma A.M Salem Olfat G Shaker Aya M Fahim |
| author_sort | Sara B Mahmoud |
| collection | DOAJ |
| description | Background Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disease that occurs due to the loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine that was initially designated as a T helper2 cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines tumor necrosis factor, IL-1, IL-17, and interferon-γ, suggesting that IL-9 is associated with the pathogenesis of autoimmune diseases.
Objective To evaluate the tissue levels of IL-9 in patients with psoriasis and vitiligo in comparison with controls, to assess the possible role of IL-9 in the pathogenesis of these diseases.
Patients and methods This case–control study included 30 patients with psoriasis, 30 patients with vitiligo, and 30 age-matched and sex-matched healthy controls. A skin biopsy was taken from all participants for evaluation of tissue IL-9 levels by enzyme-linked immunosorbent assay.
Results Tissue IL-9 was significantly higher in patients with psoriasis (28.65±18.456) and patients with vitiligo (51.056±41.536) than controls (P=0.013 and P<0.001, respectively). In addition, it was significantly higher in patients with vitiligo than in patients with psoriasis (P=0.004).
Conclusion This study suggests a possible role for IL-9 in the pathogenesis of psoriasis and vitiligo by documenting significantly higher tissue levels in patients than in controls. |
| first_indexed | 2024-03-11T14:49:36Z |
| format | Article |
| id | doaj.art-508b980075ca462ba17a7d12f0b134cb |
| institution | Directory Open Access Journal |
| issn | 2090-2565 |
| language | English |
| last_indexed | 2024-03-11T14:49:36Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Women’s Dermatologic Society |
| spelling | doaj.art-508b980075ca462ba17a7d12f0b134cb2023-10-30T09:50:16ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Women’s Dermatologic Society2090-25652023-01-0120316216710.4103/jewd.jewd_18_23Assessment of tissue level of interleukin-9 in psoriasis and vitiligoSara B MahmoudNesma A.M SalemOlfat G ShakerAya M FahimBackground Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disease that occurs due to the loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine that was initially designated as a T helper2 cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines tumor necrosis factor, IL-1, IL-17, and interferon-γ, suggesting that IL-9 is associated with the pathogenesis of autoimmune diseases. Objective To evaluate the tissue levels of IL-9 in patients with psoriasis and vitiligo in comparison with controls, to assess the possible role of IL-9 in the pathogenesis of these diseases. Patients and methods This case–control study included 30 patients with psoriasis, 30 patients with vitiligo, and 30 age-matched and sex-matched healthy controls. A skin biopsy was taken from all participants for evaluation of tissue IL-9 levels by enzyme-linked immunosorbent assay. Results Tissue IL-9 was significantly higher in patients with psoriasis (28.65±18.456) and patients with vitiligo (51.056±41.536) than controls (P=0.013 and P<0.001, respectively). In addition, it was significantly higher in patients with vitiligo than in patients with psoriasis (P=0.004). Conclusion This study suggests a possible role for IL-9 in the pathogenesis of psoriasis and vitiligo by documenting significantly higher tissue levels in patients than in controls.http://www.jewd.eg.net//article.asp?issn=1687-1537;year=2023;volume=20;issue=3;spage=162;epage=167;aulast=Mahmoudinterleukin-9psoriasisvitiligo |
| spellingShingle | Sara B Mahmoud Nesma A.M Salem Olfat G Shaker Aya M Fahim Assessment of tissue level of interleukin-9 in psoriasis and vitiligo Journal of the Egyptian Women’s Dermatologic Society interleukin-9 psoriasis vitiligo |
| title | Assessment of tissue level of interleukin-9 in psoriasis and vitiligo |
| title_full | Assessment of tissue level of interleukin-9 in psoriasis and vitiligo |
| title_fullStr | Assessment of tissue level of interleukin-9 in psoriasis and vitiligo |
| title_full_unstemmed | Assessment of tissue level of interleukin-9 in psoriasis and vitiligo |
| title_short | Assessment of tissue level of interleukin-9 in psoriasis and vitiligo |
| title_sort | assessment of tissue level of interleukin 9 in psoriasis and vitiligo |
| topic | interleukin-9 psoriasis vitiligo |
| url | http://www.jewd.eg.net//article.asp?issn=1687-1537;year=2023;volume=20;issue=3;spage=162;epage=167;aulast=Mahmoud |
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