The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors
The Nucleosome Remodelling and Deacetylase (NuRD) complex represents one of the major chromatin remodelling complexes in mammalian cells, uniquely coupling the ability to “open” the chromatin by inducing nucleosome sliding with histone deacetylase activity. At the core of the NuRD complex are a fami...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/8/1179 |
| _version_ | 1797605988099948544 |
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| author | Paraskevi Boulasiki Xiao Wei Tan Matteo Spinelli Antonella Riccio |
| author_facet | Paraskevi Boulasiki Xiao Wei Tan Matteo Spinelli Antonella Riccio |
| author_sort | Paraskevi Boulasiki |
| collection | DOAJ |
| description | The Nucleosome Remodelling and Deacetylase (NuRD) complex represents one of the major chromatin remodelling complexes in mammalian cells, uniquely coupling the ability to “open” the chromatin by inducing nucleosome sliding with histone deacetylase activity. At the core of the NuRD complex are a family of ATPases named CHDs that utilise the energy produced by the hydrolysis of the ATP to induce chromatin structural changes. Recent studies have highlighted the prominent role played by the NuRD in regulating gene expression during brain development and in maintaining neuronal circuitry in the adult cerebellum. Importantly, components of the NuRD complex have been found to carry mutations that profoundly affect neurological and cognitive development in humans. Here, we discuss recent literature concerning the molecular structure of NuRD complexes and how the subunit composition and numerous permutations greatly determine their functions in the nervous system. We will also discuss the role of the CHD family members in an array of neurodevelopmental disorders. Special emphasis will be given to the mechanisms that regulate the NuRD complex composition and assembly in the cortex and how subtle mutations may result in profound defects of brain development and the adult nervous system. |
| first_indexed | 2024-03-11T05:08:56Z |
| format | Article |
| id | doaj.art-508d23f1571346b7b2e9edaa19edbd41 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:08:56Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-508d23f1571346b7b2e9edaa19edbd412023-11-17T18:43:37ZengMDPI AGCells2073-44092023-04-01128117910.3390/cells12081179The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding DoorsParaskevi Boulasiki0Xiao Wei Tan1Matteo Spinelli2Antonella Riccio3UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UKUCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UKUCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UKUCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UKThe Nucleosome Remodelling and Deacetylase (NuRD) complex represents one of the major chromatin remodelling complexes in mammalian cells, uniquely coupling the ability to “open” the chromatin by inducing nucleosome sliding with histone deacetylase activity. At the core of the NuRD complex are a family of ATPases named CHDs that utilise the energy produced by the hydrolysis of the ATP to induce chromatin structural changes. Recent studies have highlighted the prominent role played by the NuRD in regulating gene expression during brain development and in maintaining neuronal circuitry in the adult cerebellum. Importantly, components of the NuRD complex have been found to carry mutations that profoundly affect neurological and cognitive development in humans. Here, we discuss recent literature concerning the molecular structure of NuRD complexes and how the subunit composition and numerous permutations greatly determine their functions in the nervous system. We will also discuss the role of the CHD family members in an array of neurodevelopmental disorders. Special emphasis will be given to the mechanisms that regulate the NuRD complex composition and assembly in the cortex and how subtle mutations may result in profound defects of brain development and the adult nervous system.https://www.mdpi.com/2073-4409/12/8/1179neuroepigeneticschromatin remodellingNuRDCHD4neurodevelopmentneurodegeneration |
| spellingShingle | Paraskevi Boulasiki Xiao Wei Tan Matteo Spinelli Antonella Riccio The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors Cells neuroepigenetics chromatin remodelling NuRD CHD4 neurodevelopment neurodegeneration |
| title | The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors |
| title_full | The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors |
| title_fullStr | The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors |
| title_full_unstemmed | The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors |
| title_short | The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors |
| title_sort | nurd complex in neurodevelopment and disease a case of sliding doors |
| topic | neuroepigenetics chromatin remodelling NuRD CHD4 neurodevelopment neurodegeneration |
| url | https://www.mdpi.com/2073-4409/12/8/1179 |
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