EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea
Chan Zhang,1,2,* Yanhui Wang,1,4,* Dongxiao Li,3 Mengjie Li,1,4 Xiaofeng Zhang,1,2 Wenzheng Rong,1,2 Pu Wang,1 Lanjun Li,1,2 Shujing He,1,2 Yuming Xu,1,2 Yusheng Li1,2 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, He...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/eeg-power-spectral-density-in-nrem-sleep-is-associated-with-the-degree-peer-reviewed-fulltext-article-NSS |
| _version_ | 1827631268403085312 |
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| author | Zhang C Wang Y Li D Li M Zhang X Rong W Wang P Li L He S Xu Y Li Y |
| author_facet | Zhang C Wang Y Li D Li M Zhang X Rong W Wang P Li L He S Xu Y Li Y |
| author_sort | Zhang C |
| collection | DOAJ |
| description | Chan Zhang,1,2,* Yanhui Wang,1,4,* Dongxiao Li,3 Mengjie Li,1,4 Xiaofeng Zhang,1,2 Wenzheng Rong,1,2 Pu Wang,1 Lanjun Li,1,2 Shujing He,1,2 Yuming Xu,1,2 Yusheng Li1,2 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China; 2NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Zhengzhou, Henan, People’s Republic of China; 3Henan Neurodevelopment Engineering Research Center for Children, Henan Key Laboratory of Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 450018, People’s Republic of China; 4The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuming Xu; Yusheng Li, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China, Tel +86-18236145799, Fax +86-371-66862134, Email xuyuming@zzu.edu.cn; fccliyusheng@zzu.edu.cnPurpose: Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder. Research conducted on patients with OSA using electroencephalography (EEG) has revealed a noticeable shift in the overnight polysomnography (PSG) power spectrum. To better quantify the effects of OSA on brain function and to identify the most reliable predictors of pathological cortical activation, this study quantified the PSG power and its association with the degree of hypoxia in OSA patients.Patients and Methods: This retrospective study recruited 93 patients with OSA. OSA patients were divided into three groups based on their apnea-hypopnea index (AHI) scores. The clinical characteristics and sleep macrostructure of these patients were examined, followed by an analysis of PSG signals. Power spectral density (PSD) in five frequency bands was analyzed during nonrapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and wakefulness. Finally, correlation analysis was conducted to assess the relationships among PSD, PSG parameters, and serum levels of S100β and uric acid.Results: Obstructive sleep apnea occurred during both the NREM and REM sleep phases. Except for a decrease in the duration of N2 sleep and an increase in the microarousal index, there were no significant differences in sleep architecture based on disease severity. Compared to the mild OSA group, the theta and alpha band PSD in the frontal and occipital regions during NREM sleep and wakefulness were significantly decreased in the moderate and severe OSA groups. Correlation analysis revealed that theta PSD in N1 and N3 stages were negatively correlated the AHI, oxygen desaturation index, SaO2< 90% and microarousal index.Conclusion: These findings imply that patients with more severe OSA exhibited considerable NREM hypoxia and abnormal brain activity in the frontal and occipital regions. Therefore, sleep EEG oscillation may be a useful neurophysiological indicator for assessing brain function and disease severity in patients with OSA.Keywords: obstructive sleep apnea, OSA, quantitative EEG, polysomnography, power spectral density, nonrapid eye movement sleep, serum markers |
| first_indexed | 2024-03-09T14:19:35Z |
| format | Article |
| id | doaj.art-508e22ffbdd84f10a2702e3bc6bd80aa |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-03-09T14:19:35Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-508e22ffbdd84f10a2702e3bc6bd80aa2023-11-28T17:15:53ZengDove Medical PressNature and Science of Sleep1179-16082023-11-01Volume 1597999288510EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep ApneaZhang CWang YLi DLi MZhang XRong WWang PLi LHe SXu YLi YChan Zhang,1,2,* Yanhui Wang,1,4,* Dongxiao Li,3 Mengjie Li,1,4 Xiaofeng Zhang,1,2 Wenzheng Rong,1,2 Pu Wang,1 Lanjun Li,1,2 Shujing He,1,2 Yuming Xu,1,2 Yusheng Li1,2 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China; 2NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Zhengzhou, Henan, People’s Republic of China; 3Henan Neurodevelopment Engineering Research Center for Children, Henan Key Laboratory of Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 450018, People’s Republic of China; 4The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuming Xu; Yusheng Li, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China, Tel +86-18236145799, Fax +86-371-66862134, Email xuyuming@zzu.edu.cn; fccliyusheng@zzu.edu.cnPurpose: Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder. Research conducted on patients with OSA using electroencephalography (EEG) has revealed a noticeable shift in the overnight polysomnography (PSG) power spectrum. To better quantify the effects of OSA on brain function and to identify the most reliable predictors of pathological cortical activation, this study quantified the PSG power and its association with the degree of hypoxia in OSA patients.Patients and Methods: This retrospective study recruited 93 patients with OSA. OSA patients were divided into three groups based on their apnea-hypopnea index (AHI) scores. The clinical characteristics and sleep macrostructure of these patients were examined, followed by an analysis of PSG signals. Power spectral density (PSD) in five frequency bands was analyzed during nonrapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and wakefulness. Finally, correlation analysis was conducted to assess the relationships among PSD, PSG parameters, and serum levels of S100β and uric acid.Results: Obstructive sleep apnea occurred during both the NREM and REM sleep phases. Except for a decrease in the duration of N2 sleep and an increase in the microarousal index, there were no significant differences in sleep architecture based on disease severity. Compared to the mild OSA group, the theta and alpha band PSD in the frontal and occipital regions during NREM sleep and wakefulness were significantly decreased in the moderate and severe OSA groups. Correlation analysis revealed that theta PSD in N1 and N3 stages were negatively correlated the AHI, oxygen desaturation index, SaO2< 90% and microarousal index.Conclusion: These findings imply that patients with more severe OSA exhibited considerable NREM hypoxia and abnormal brain activity in the frontal and occipital regions. Therefore, sleep EEG oscillation may be a useful neurophysiological indicator for assessing brain function and disease severity in patients with OSA.Keywords: obstructive sleep apnea, OSA, quantitative EEG, polysomnography, power spectral density, nonrapid eye movement sleep, serum markershttps://www.dovepress.com/eeg-power-spectral-density-in-nrem-sleep-is-associated-with-the-degree-peer-reviewed-fulltext-article-NSSobstructive sleep apneaosaquantitative eegpolysomnographypower spectral densitynonrapid eye movement sleepserum markers |
| spellingShingle | Zhang C Wang Y Li D Li M Zhang X Rong W Wang P Li L He S Xu Y Li Y EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea Nature and Science of Sleep obstructive sleep apnea osa quantitative eeg polysomnography power spectral density nonrapid eye movement sleep serum markers |
| title | EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea |
| title_full | EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea |
| title_fullStr | EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea |
| title_full_unstemmed | EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea |
| title_short | EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea |
| title_sort | eeg power spectral density in nrem sleep is associated with the degree of hypoxia in patients with obstructive sleep apnea |
| topic | obstructive sleep apnea osa quantitative eeg polysomnography power spectral density nonrapid eye movement sleep serum markers |
| url | https://www.dovepress.com/eeg-power-spectral-density-in-nrem-sleep-is-associated-with-the-degree-peer-reviewed-fulltext-article-NSS |
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