A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population.

A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population.

BACKGROUND: Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) in Caucasian populations of European descent. In particular, a nonsynonymous coding variant, rs2230199 (R102G), is presumed to be the most likely causal v...

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Bibliographic Details
Main Authors: Suiho Yanagisawa, Naoshi Kondo, Akiko Miki, Wataru Matsumiya, Sentaro Kusuhara, Yasutomo Tsukahara, Shigeru Honda, Akira Negi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3236234?pdf=render

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