Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain
Chest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emer...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.867155/full |
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| author | Ashley S. Manchanda Alan C. Kwan Alan C. Kwan Alan C. Kwan Mariko Ishimori Louise E. J. Thomson Debiao Li Daniel S. Berman Daniel S. Berman Daniel S. Berman C. Noel Bairey Merz C. Noel Bairey Merz Caroline Jefferies Janet Wei Janet Wei Janet Wei |
| author_facet | Ashley S. Manchanda Alan C. Kwan Alan C. Kwan Alan C. Kwan Mariko Ishimori Louise E. J. Thomson Debiao Li Daniel S. Berman Daniel S. Berman Daniel S. Berman C. Noel Bairey Merz C. Noel Bairey Merz Caroline Jefferies Janet Wei Janet Wei Janet Wei |
| author_sort | Ashley S. Manchanda |
| collection | DOAJ |
| description | Chest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emerging evidence suggests that ischemia with no obstructive coronary arteries (INOCA) is a prevalent condition in patients with chest pain and no obstructive coronary artery disease. Coronary microvascular dysfunction is reported in approximately half of SLE patients with suspected INOCA. In this mini review, we highlight the cardiovascular risk assessment, mechanisms of INOCA, and diagnostic approach for patients with SLE and suspected CMD. |
| first_indexed | 2024-12-12T19:44:02Z |
| format | Article |
| id | doaj.art-508e59d0214c4c68ae082ddb4c0c1b1c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T19:44:02Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-508e59d0214c4c68ae082ddb4c0c1b1c2022-12-22T00:14:09ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.867155867155Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest PainAshley S. Manchanda0Alan C. Kwan1Alan C. Kwan2Alan C. Kwan3Mariko Ishimori4Louise E. J. Thomson5Debiao Li6Daniel S. Berman7Daniel S. Berman8Daniel S. Berman9C. Noel Bairey Merz10C. Noel Bairey Merz11Caroline Jefferies12Janet Wei13Janet Wei14Janet Wei15Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Imaging, Mark Taper Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDivision of Rheumatology and Department of Biomedical Sciences, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Imaging, Mark Taper Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Imaging, Mark Taper Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBarbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDivision of Rheumatology and Department of Biomedical Sciences, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBarbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCedars-Sinai Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesChest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emerging evidence suggests that ischemia with no obstructive coronary arteries (INOCA) is a prevalent condition in patients with chest pain and no obstructive coronary artery disease. Coronary microvascular dysfunction is reported in approximately half of SLE patients with suspected INOCA. In this mini review, we highlight the cardiovascular risk assessment, mechanisms of INOCA, and diagnostic approach for patients with SLE and suspected CMD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.867155/fullsystemic lupus erythematosuschest paincoronary microvascular dysfunctioncoronary vasospasmischemic heart disease |
| spellingShingle | Ashley S. Manchanda Alan C. Kwan Alan C. Kwan Alan C. Kwan Mariko Ishimori Louise E. J. Thomson Debiao Li Daniel S. Berman Daniel S. Berman Daniel S. Berman C. Noel Bairey Merz C. Noel Bairey Merz Caroline Jefferies Janet Wei Janet Wei Janet Wei Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain Frontiers in Cardiovascular Medicine systemic lupus erythematosus chest pain coronary microvascular dysfunction coronary vasospasm ischemic heart disease |
| title | Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain |
| title_full | Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain |
| title_fullStr | Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain |
| title_full_unstemmed | Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain |
| title_short | Coronary Microvascular Dysfunction in Patients With Systemic Lupus Erythematosus and Chest Pain |
| title_sort | coronary microvascular dysfunction in patients with systemic lupus erythematosus and chest pain |
| topic | systemic lupus erythematosus chest pain coronary microvascular dysfunction coronary vasospasm ischemic heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.867155/full |
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