The Open Question of How GPCRs Interact with GPCR Kinases (GRKs)

The Open Question of How GPCRs Interact with GPCR Kinases (GRKs)

G protein-coupled receptors (GPCRs), which regulate a vast number of eukaryotic processes, are desensitized by various mechanisms but, most importantly, by the GPCR kinases (GRKs). Ever since GRKs were first identified, investigators have sought to determine which structural features of GRKs are use...

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Bibliographic Details
Main Authors: M. Claire Cato, Yu-Chen Yen, Charnelle J. Francis, Kaely E. Elkins, Afzaal Shareef, Rachel Sterne-Marr, John J. G. Tesmer
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
G protein-coupled receptor
G protein-coupled receptor kinase
protein structure
phosphorylation
complexes
allostery
Online Access:https://www.mdpi.com/2218-273X/11/3/447

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